PLLA-Azide (PLLA-N3), MW 10K is an azide-functionalized poly(L-lactide) with a molecular weight of approximately 10K. It combines a biodegradable PLLA backbone with terminal azide functionality specifically for click chemistry, bioconjugation, polymer functionalization, drug delivery, and biomaterial research.
Key Features and Benefits
- Azide-Functionalized PLLA: Combines biodegradable poly(L-lactide) with a terminal azide group for chemical modification and conjugation.
- MW 10K: Provides a lower molecular weight with good processability for polymer functionalization, formulation, and conjugation research.
- Azide Functionality: The terminal –N3 group provides a reactive site specifically for azide-alkyne click chemistry and related conjugation strategies.
- Biodegradable Polyester: The PLLA backbone contains hydrolyzable ester linkages that specifically support gradual polymer degradation under appropriate conditions.
- Stereoregular PLLA Backbone: The L-lactide-derived polymer structure promotes crystallinity and provides useful structural and thermal properties.
- Click Chemistry Platform: The azide terminus supports Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC) with terminal alkynes.
- Copper-Free Conjugation: The azide group supports strain-promoted azide-alkyne cycloaddition (SPAAC) with compatible strained cyclooctynes.
- Versatile Functionalization: Terminal azide functionality enables attachment of compatible polymers, biomolecules, probes, ligands, and other functional components.
Applications
- CuAAC Click Chemistry: Supports conjugation with terminal alkyne-functionalized molecules, polymers, and surfaces.
- Copper-Free Click Chemistry: Supports SPAAC reactions with DBCO, BCN, and other compatible strained cyclooctyne-functionalized components.
- Bioconjugation: Provides terminal azide functionality for coupling PLLA with compatible biomolecules and functional ligands.
- Polymer Functionalization: Enables preparation of functional PLLA derivatives and more complex polymer architectures.
- Nanoparticle Functionalization: Supports preparation and surface modification of biodegradable polymer nanoparticles and related delivery systems.
- Drug Delivery: Supports development of functional biodegradable polymer systems specifically for drug-delivery and controlled-release research.
- Surface Modification: Enables attachment of PLLA to compatible alkyne- or cyclooctyne-functionalized surfaces and materials.
- Biomaterial Research: Supports development of functional biodegradable polymers, particles, coatings, composites, and related biomaterials.
Storage and Handling
- Storage: Store at –20 °C in a tightly sealed container under dry conditions. Protect from moisture and excessive heat.
- Handling: Protect from moisture and excessive heat. Allow the material to equilibrate to room temperature before opening to minimize moisture condensation.
PLLA-Azide (PLLA-N3), MW 10K provides a biodegradable PLLA platform with terminal azide functionality and good processability for selective click chemistry and conjugation. It specifically supports bioconjugation, polymer functionalization, nanoparticle modification, drug delivery, and biomaterial research.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.