PDLLA-Thiol (PDLLA-SH), MW 2K is a thiol-functionalized poly(DL-lactide) with a molecular weight of approximately 2K. It combines a low-molecular-weight, biodegradable amorphous PDLLA backbone with terminal thiol functionality specifically for bioconjugation, surface modification, nanoparticle functionalization, polymer coupling, and biomaterial research.
Key Features and Benefits
- Thiol-Functionalized PDLLA: Combines biodegradable poly(DL-lactide) with a terminal thiol group for chemical modification and conjugation.
- MW 2K: Provides a low molecular weight with good processability specifically for polymer functionalization, formulation, and conjugation research.
- Thiol Functionality: The terminal –SH group provides a reactive site specifically for thiol-selective coupling and surface attachment.
- Biodegradable Polyester: The PDLLA backbone contains hydrolyzable ester linkages that support gradual polymer degradation under appropriate conditions.
- Amorphous PDLLA Backbone: The random distribution of D- and L-lactide units limits crystallization and provides an amorphous polymer structure.
- Good Processability: The low molecular weight facilitates polymer dissolution, formulation, and chemical modification compared with higher-molecular-weight PDLLA grades.
- Conjugation Platform: The thiol terminus supports reactions with maleimide, vinyl sulfone, disulfide-forming reagents, and other thiol-reactive functionalities.
- Surface Affinity: Thiol functionality supports attachment to compatible metal surfaces, including gold, for surface and nanoparticle modification research.
Applications
- Bioconjugation: Provides terminal thiol functionality for coupling PDLLA with thiol-reactive molecules and biomolecular components.
- Thiol-Maleimide Coupling: Supports conjugation with maleimide-functionalized molecules, polymers, and surfaces.
- Surface Modification: Enables functionalization of compatible surfaces through thiol-mediated attachment or coupling reactions.
- Nanoparticle Functionalization: Supports preparation and surface modification of biodegradable polymer nanoparticles and hybrid nanomaterials.
- Gold Surface Functionalization: The thiol group supports interaction with gold surfaces and gold nanoparticles for materials research.
- Polymer Conjugation: Provides a reactive terminal group for preparing block, graft, and other functional polymer architectures.
- Drug Delivery: Supports development of functional biodegradable polymer systems for drug-delivery and controlled-release research.
- Biomaterial Research: Supports development of functional biodegradable polymers, coatings, particles, composites, and related biomaterials.
Storage and Handling
- Storage: Store at –20 °C in a tightly sealed container under dry conditions. Protect from moisture and prolonged exposure to air.
- Handling: Minimize exposure to oxygen and moisture to reduce thiol oxidation and disulfide formation. Allow the material to equilibrate to room temperature before opening to minimize moisture condensation.
PDLLA-Thiol (PDLLA-SH), MW 2K provides a low-molecular-weight, amorphous biodegradable PDLLA platform with terminal thiol functionality and good processability and specifically supports bioconjugation, surface modification, nanoparticle functionalization, polymer coupling, and biomaterial research.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.