PDLLA-Thiol (PDLLA-SH), MW 20K is a thiol-functionalized poly(DL-lactide) with a molecular weight of approximately 20K. It combines a biodegradable amorphous PDLLA backbone with terminal thiol functionality specifically for bioconjugation, surface modification, nanoparticle functionalization, polymer coupling, and biomaterial research.
Key Features and Benefits
- Thiol-Functionalized PDLLA: Combines biodegradable poly(DL-lactide) with a terminal thiol group for chemical modification and conjugation.
- MW 20K: Provides a moderate molecular weight that specifically balances polymer processability, biodegradable matrix formation, and functionalization.
- Thiol Functionality: The terminal –SH group provides a reactive site for thiol-selective coupling and surface attachment.
- Biodegradable Polyester: The PDLLA backbone contains hydrolyzable ester linkages that specifically support gradual polymer degradation under appropriate conditions.
- Amorphous PDLLA Backbone: The random distribution of D- and L-lactide units limits crystallization and provides an amorphous polymer structure.
- Conjugation Platform: The thiol terminus supports reactions with maleimide, vinyl sulfone, disulfide-forming reagents, and other thiol-reactive functionalities.
- Surface Affinity: Thiol functionality supports attachment to compatible metal surfaces, including gold, for surface and nanoparticle modification research.
Applications
- Bioconjugation: Provides terminal thiol functionality for coupling PDLLA with thiol-reactive molecules and biomolecular components.
- Thiol-Maleimide Coupling: Supports conjugation with maleimide-functionalized molecules, polymers, and surfaces.
- Surface Modification: Enables functionalization of compatible surfaces through thiol-mediated attachment or coupling reactions.
- Nanoparticle Functionalization: Supports preparation and surface modification of biodegradable polymer nanoparticles and hybrid nanomaterials.
- Gold Surface Functionalization: The thiol group supports interaction with gold surfaces and gold nanoparticles for materials research.
- Polymer Conjugation: Provides a reactive terminal group for preparing block, graft, and other functional polymer architectures.
- Drug Delivery: Supports development of functional biodegradable polymer systems for drug-delivery and controlled-release research.
- Biomaterial Research: Supports development of functional biodegradable polymers, coatings, particles, composites, and related biomaterials.
Storage and Handling
- Storage: Store at –20 °C in a tightly sealed container under dry conditions. Protect from moisture and prolonged exposure to air.
- Handling: Minimize exposure to oxygen and moisture to reduce thiol oxidation and disulfide formation. Allow the material to equilibrate to room temperature before opening to minimize moisture condensation.
PDLLA-Thiol (PDLLA-SH), MW 20K provides an amorphous biodegradable PDLLA platform with terminal thiol functionality for selective conjugation and surface modification and specifically supports bioconjugation, nanoparticle functionalization, polymer coupling, drug delivery, and biomaterial research.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.