α‑Hydroxyl‑ω‑Thiol‑poly(D,L‑lactide) (PDLLA‑SH, MW 10K) is linear, mono‑thiol‑terminated fully amorphous biodegradable aliphatic polyester. D‑lactide and L‑lactide repeat units are randomly distributed along polymer backbone, disrupting stereoregularity and eliminating crystalline domains. Compared with MW 5K PDLLA‑SH, this 10 kDa grade presents higher hydrophobicity and slower homogeneous hydrolytic degradation. One polymer terminus bears reactive free thiol (‑SH) group, the opposite terminus retains inert hydroxyl (‑OH). Terminal thiol can participate in thiol‑maleimide click coupling, disulfide bond formation, thiol‑ene Michael‑addition reactions, enabling covalent conjugation with maleimide‑modified ligands, peptides and biomolecules under mild conditions. It works as monofunctional macromonomer for nanoparticle surface modification, redox‑responsive material construction and long‑term biodegradable biomedical delivery research.
Key Features
- MW: 10000 Da, linear α‑hydroxyl‑ω‑thiol‑terminated poly(D,L‑lactide)
- Fully amorphous non‑crystalline structure, random D/L‑lactide sequence, no melting point
- Higher hydrophobicity, slower and uniform hydrolytic degradation versus 5K PDLLA‑SH
- Excellent biocompatibility; degradation produces non‑toxic lactic‑acid metabolites
- Single terminal free thiol (‑SH) group; capable of maleimide coupling, disulfide formation and thiol‑ene reaction; opposite polymer end is inert hydroxyl ‑OH
- Narrow molecular‑weight distribution, stable batch‑to‑batch reproducibility; high thiol end‑group functionality
- Soluble in DCM, CHCl₃, THF, DMF, hot acetone; insoluble in water
- Thiol group is oxidation‑sensitive; strictly avoid air exposure, moisture and heavy‑metal contaminants
Applications
- Monofunctional building block for thiol‑click bioconjugation with maleimide‑activated peptides, ligands and biomacromolecules
- Fabrication of redox‑responsive disulfide‑crosslinked PDLLA nanoparticles and microspheres for long‑term drug‑delivery study
- Thiol‑functional surface engineering of slow‑degrading PDLLA nanocarriers and polymer coatings
- Research‑grade raw material for constructing reactive‑site‑modified high‑molecular‑weight biodegradable polyester biomaterials
Handling & Storage
- Store at −20 °C under dry inert nitrogen or argon atmosphere; strictly moisture‑proof and oxygen‑shielded
- Keep hermetically sealed; oxygen and moisture trigger thiol oxidation to form disulfide impurities; avoid repeated freeze‑thaw cycles
- For research‑only use; not intended for clinical or diagnostic applications
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.