PDLLA-Acid (PDLLA-COOH), MW 2K is a carboxyl-functionalized poly(DL-lactide) with a molecular weight of approximately 2K. It combines a low-molecular-weight, biodegradable amorphous PDLLA backbone with terminal carboxyl functionality specifically for bioconjugation, polymer functionalization, surface modification, nanoparticle functionalization, and biomaterial research.
Key Features and Benefits
- Carboxyl-Functionalized PDLLA: Combines biodegradable poly(DL-lactide) with a terminal carboxyl group for chemical modification and conjugation.
- MW 2K: Provides a low molecular weight with good processability specifically for polymer functionalization, formulation, and conjugation research.
- Carboxyl Functionality: The terminal –COOH group provides a reactive site for coupling with amine-containing molecules through appropriate activation chemistry.
- Biodegradable Polyester: The PDLLA backbone contains hydrolyzable ester linkages that specifically support gradual polymer degradation under appropriate conditions.
- Amorphous PDLLA Backbone: The random distribution of D- and L-lactide units limits crystallization and provides an amorphous polymer structure.
- Good Processability: The low molecular weight specifically facilitates polymer dissolution, formulation, and chemical modification compared with higher-molecular-weight PDLLA grades.
- Amide Coupling Platform: The carboxyl terminus supports activation with EDC/NHS and other suitable coupling reagents for reaction with primary amines.
Applications
- Bioconjugation: Supports coupling of PDLLA with amine-containing biomolecules, peptides, proteins, ligands, and other functional components.
- EDC/NHS Coupling: Enables activation of the terminal carboxyl group for conjugation with primary amines.
- Amide Bond Formation: Supports formation of stable amide linkages with compatible amine-functionalized molecules and materials.
- Polymer Functionalization: Enables preparation of functional PDLLA derivatives and more complex polymer architectures.
- Nanoparticle Functionalization: Supports preparation and surface modification of biodegradable polymer nanoparticles and related delivery systems.
- Surface Modification: Enables incorporation of carboxyl functionality into PDLLA-containing surfaces, coatings, and materials.
- Drug Delivery: Supports development of functional biodegradable polymer systems for drug-delivery and controlled-release research.
- Biomaterial Research: Supports development of functional biodegradable polymers, particles, coatings, composites, and related biomaterials.
Storage and Handling
- Storage: Store at –20 °C in a tightly sealed container under dry conditions. Protect from moisture and excessive heat.
- Handling: Protect from moisture and excessive heat. Allow the material to equilibrate to room temperature before opening to minimize moisture condensation.
PDLLA-Acid (PDLLA-COOH), MW 2K provides a low-molecular-weight, amorphous biodegradable PDLLA platform with terminal carboxyl functionality and good processability and specifically supports bioconjugation, polymer functionalization, nanoparticle modification, surface modification, and biomaterial research.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.