PCL Diacid (HOOC-PCL-COOH), MW 10K is a carboxyl-terminated poly(ε-caprolactone) with carboxylic acid groups at both polymer chain ends. It combines a biodegradable PCL backbone with two terminal carboxyl groups specifically for polymer conjugation, bioconjugation, surface modification, crosslinking, and biomaterial research.
Key Features and Benefits
- Difunctional PCL: Contains terminal carboxyl groups at both ends of the PCL chain, providing two reactive sites for functionalization and conjugation.
- MW 10K: Provides a moderate molecular weight with good processability specifically for polymer functionalization, formulation, and conjugation research.
- Carboxyl Functionality: The terminal –COOH groups provide reactive sites specifically for coupling with amine-containing molecules through appropriate activation chemistry.
- Biodegradable Polyester: The PCL backbone contains hydrolyzable ester linkages that specifically support gradual polymer degradation under appropriate conditions.
- Semicrystalline PCL Backbone: The PCL structure supports semicrystalline polymer formation and provides useful material-forming properties for biodegradable polymer research.
- Amide Coupling Platform: The terminal carboxyl groups support activation with EDC/NHS and other suitable coupling reagents for reaction with primary amines.
- Difunctional Conjugation Platform: Two terminal carboxyl groups enable chain extension, crosslinking, end-group modification, and preparation of more complex polymer architectures.
Applications
- Polymer Conjugation: Supports coupling with amine-functionalized polymers and other compatible molecules to prepare block, multiblock, and functional polymer systems.
- EDC/NHS Coupling: Enables activation of terminal carboxyl groups for conjugation with primary amines.
- Amide Bond Formation: Supports formation of stable amide linkages with compatible amine-functionalized molecules and materials.
- Bioconjugation: Enables attachment of compatible peptides, proteins, ligands, and other amine-containing biomolecules.
- Crosslinking: The two terminal carboxyl groups support development of crosslinked or networked polymer systems using suitable multifunctional coupling partners.
- Surface Modification: Enables incorporation of carboxyl-functional PCL into functional surfaces, coatings, and polymeric materials.
- Drug Delivery: Supports development of biodegradable polymer systems for drug-delivery and controlled-release research.
- Biomaterial Research: Supports development of biodegradable polymers, particles, coatings, composites, networks, and related biomaterials.
Storage and Handling
- Storage: Store at –20 °C in a tightly sealed container under dry conditions. Protect from moisture and excessive heat.
- Handling: Protect from moisture and excessive heat. Allow the material to equilibrate to room temperature before opening to minimize moisture condensation.
PCL Diacid (HOOC-PCL-COOH), MW 10K provides a biodegradable PCL platform with carboxyl groups at both chain ends and good processability and specifically supports amide coupling, chain extension, crosslinking, bioconjugation, surface modification, and biomaterial research.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.