PCL Diacid (HOOC‑PCL‑COOH, MW 3K) is a linear α,ω‑dicarboxyl‑terminated biodegradable aliphatic polyester. Compared with MW 2K PCL Diacid, the 3 kDa polymer exhibits increased hydrophobicity and crystallinity, together with a reduced hydrolytic degradation rate. Dual terminal carboxylic acid groups can be activated via EDC/NHS chemistry to form amide bonds with amine‑containing peptides, proteins and small‑molecule therapeutics. It serves as a key bifunctional building block for constructing block copolymers, cross‑linked polymer networks, polymer‑drug conjugates and functional biodegradable biomaterials in biomedical research.
Key Features
- MW: 3000 Da, linear polycaprolactone with carboxyl groups at both chain ends
- Higher hydrophobicity and crystallinity, slower hydrolysis versus 2K PCL Diacid
- Biocompatible semi‑crystalline biodegradable polyester
- Dual reactive‑COOH termini, activatable by EDC/NHS for amine‑amide coupling
- Narrow molecular weight distribution, reliable batch‑to‑batch consistency
- Soluble in DCM, CHCl₃, THF, DMF; insoluble in water
Applications
- Precursor for synthesis of PCL‑based block copolymers and cross‑linked polymer networks
- Bioconjugation with amine‑functionalized peptides, proteins and drug molecules after EDC/NHS activation
- Preparation of amide‑bonded polymer‑drug conjugates for drug‑delivery studies
- Carboxyl‑functional surface modification of biodegradable biomaterial scaffolds
- Synthetic intermediate for degradable polyurethane and polyester materials
Handling & Storage
- Store at −20 °C under dry inert nitrogen or argon atmosphere
- Keep hermetically sealed and dry, avoid moisture‑induced side‑reactions; prevent repeated freeze‑thaw cycles
- For research‑only use; not intended for clinical or diagnostic applications
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.