PLGA-Rhodamine B (PLGA-RhB), MW 20K is an ultra-high-molecular-weight, red fluorescent labeled biodegradable PLGA copolymer covalently conjugated with Rhodamine B (RhB) fluorophore. Featuring ultra-rigid structural performance, exceptional morphological durability and ultra-long slow hydrolytic degradation kinetics, this fluorescent polymer delivers ultra-stable, high-brightness red fluorescence for multi-month ultra-long-cycle in vivo tracing, implantable carrier biodistribution analysis and long-term biomedical visualization. It supports fully tunable PLGA compositions and custom molecular weight preparation, serving as a premium high-durability fluorescent tracking material for ultra-long-acting sustained drug delivery and advanced translational biomedical imaging research.
Basic Specifications
Alternative Name: PLGA-RhB, Rhodamine B-PLGA
PLGA Composition: 50:50, 65:35, 75:25, 85:15, Custom
Molecular Weight: Custom
Fluorescent Label: Rhodamine B (RhB)
Excitation Wavelength: ~554 nm
Emission Wavelength: ~576 nm
Appearance: Pink to light red solid
Key Features and Benefits
Stable Covalent Rhodamine B Labeling: Rhodamine B fluorophore is firmly covalently bonded to the PLGA polymer chain terminal, completely avoiding free dye shedding, leakage and non-specific background fluorescence interference. The polymer maintains ultra-bright, consistent red fluorescent signals throughout multi-month polymer degradation and long-term in vivo circulation processes, delivering ultra-high reliability and repeatability for ultra-long-cycle fluorescent tracing experiments.
Fully Tunable PLGA Composition: Covers all mainstream lactide-glycolide ratios including 50:50, 65:35, 75:25, 85:15, and supports personalized custom synthesis. Precise ratio modulation flexibly adjusts polymer hydrophilicity, ultra-long degradation kinetics and mechanical toughness, fully adapting to ultra-long-acting sustained-release formulations and high-standard implantable biomedical imaging research scenarios.
Ultra-Stable 20K Ultra-High Molecular Weight Performance: The 20K ultra-high molecular weight forms extremely dense polymer chain entanglement, possessing industry-leading structural rigidity, anti-deformation toughness and morphological stability compared with low and medium-high MW PLGA. It exhibits uniform, ultra-slow hydrolytic degradation behavior, effectively eliminating nanoparticle structural collapse, fatigue damage and premature drug release, perfectly suitable for fabricating ultra-stable fluorescent nanoparticles and microspheres for multi-month long-duration tracing research.
Excellent Biocompatibility & Low Cytotoxicity: Features premium physiological biocompatibility and clinical-grade biosafety. The PLGA backbone undergoes mild, homogeneous hydrolysis into endogenous non-toxic lactic acid and glycolic acid over ultra-long cycles. The covalently immobilized RhB fluorophore triggers no cellular toxicity, tissue irritation or inflammatory response, fully complying with safety standards for ultra-long-term in vitro cell imaging and multi-month in vivo implantable tracing applications.
High Signal Anti-Interference Ability: Rhodamine B long-wavelength red fluorescence effectively avoids autofluorescence interference from biological tissues, cell culture media and extracellular matrices. It provides an ultra-high signal-to-noise ratio and superior imaging resolution, enabling precise visualization of long-term nanoparticle cellular internalization, intracellular trafficking, tissue accumulation and in vivo metabolic distribution behavior.
Applications
Ultra-Long-Cycle Fluorescent Particle Tracing: Specialized for real-time fluorescent monitoring and dynamic behavior analysis of ultra-stable implantable PLGA nanoparticles, microspheres and durable hydrogel carriers, supporting multi-month long-duration research on particle transport, tissue retention and in vivo distribution rules.
Advanced Translational Biomedical Optical Imaging: Ideal for ultra-long-duration cell fluorescence imaging, long-term in vivo tissue section tracing and biodistribution & metabolism evaluation of ultra-long-acting sustained-release systems, providing intuitive optical data for implantable formulation optimization and long-term delivery mechanism research.
Multi-Month Sustained-Release Formulation Verification: Applied for visual tracking of ultra-long-term polymer degradation and sustained drug release kinetics, enabling intuitive evaluation of structural stability, release uniformity and persistent therapeutic efficacy of multi-month long-acting formulations.
Long-Duration Implantable Biomaterial Analysis: Serves as a high-durability fluorescent marker for ultra-long-cycle degradable tissue engineering scaffolds and implantable biomedical carriers, supporting multi-month in vivo material retention, metabolic processes and long-term biocompatibility evaluation.
Storage and Handling
Storage: Store at –20 °C in a sealed, dry, light-proof and moisture-proof container to prevent fluorescence quenching and polymer hydrolysis, effectively protecting long-term fluorescent activity and polymer structural integrity.
Handling: Avoid prolonged strong light irradiation, high-temperature environment and repeated freeze-thaw cycles to prevent RhB fluorescence attenuation and polymer performance degradation.
PLGA-Rhodamine B (PLGA-RhB), MW 20K integrates ultra-high structural stability, multi-month long-cycle fluorescent tracing performance and ultra-slow degradability, serving as a premium implantable-grade fluorescent biodegradable polymer for ultra-long-term nanoparticle tracing, translational biomedical imaging and multi-month sustained-release formulation visualization research.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.