PLGA-di-Biotin, MW 20K is an ultra-high-molecular-weight dual-biotin functionalized biodegradable PLGA copolymer with dual-terminal biotin modification. Featuring ultra-high structural rigidity and ultra-long-cycle degradability, this polymer enables high-density biotin-avidin crosslinking and ultra-stable targeted drug delivery. It supports full tunable lactide-glycolide ratios and custom formulation services, perfectly suited for high-rigidity nanoparticle fabrication, durable biomaterial crosslinking and long-term in vivo biomedical research.
Basic Specifications
Polymer Composition: Poly(D,L-lactide-co-glycolic acid)-di-Biotin
Lactide:Glycolide Ratio: 50:50, 65:35, 75:25, 85:15, Custom
Molecular Weight: 20K, Custom
Key Features and Benefits
Dual-Biotin Terminal Functionalization: Dual-end biotin capping delivers double independent high-affinity biotin binding sites, offering higher conjugation density, stronger crosslinking force and better binding stability than single-biotin PLGA polymers. It supports multi-point biomolecule immobilization and long-term durable surface functionalization for complex in vivo biological systems.
Multi-Ratio Tunable Formulation: Provides standard 50:50, 65:35, 75:25, 85:15 and fully customized lactide-glycolide ratios. Accurate ratio regulation precisely adjusts polymer hydrophobicity, mechanical toughness and ultra-long degradation cycle, meeting the preparation requirements of long-acting sustained-release and high-stability biomaterial formulations.
Ultra-Stable 20K Molecular Weight Performance: Ultra-high 20K molecular weight forms dense polymer chain entanglement, endowing the material with excellent structural rigidity, anti-deformation performance and morphological stability. Compared with 10K and low/medium MW PLGA, it features significantly prolonged degradation time, effectively avoiding particle rupture and drug leakage for ultra-long-cycle delivery systems.
Excellent Biocompatibility & Biodegradability: Possesses superior physiological biocompatibility and biosafety, slowly and uniformly hydrolyzing into non-toxic lactic acid and glycolic acid in vivo. No inflammatory stimulation or residual toxicity, fully applicable for long-term implantation and prolonged biomedical tracking research.
High-Density Cross-Linking & Ultra-Long Targeting Stability: Dual-biotin active sites greatly improve polymer crosslinking density and surface functional activity, significantly enhancing the structural durability and targeted recognition stability of drug carriers, ideal for long-term targeted therapy and stable biomaterial construction.
Applications
Ultra-Stable Biotin-Avidin Bioconjugation: Suitable for high-density, multi-point stable coupling with streptavidin-modified antibodies, functional proteins, biological probes and targeted ligands for long-term stable biological modification and labeling.
Ultra-Long-Cycle Targeted Drug Delivery: Optimized for preparing high-rigidity deformation-resistant PLGA nanoparticles and microspheres, realizing multi-month ultra-long sustained release and stable targeted enrichment for chronic disease long-acting treatment formulations.
Durable Biomaterial Cross-Linking & Functionalization: Serves as a high-performance dual-functional crosslinker for constructing long-acting biotin-modified hydrogels, implantable biodegradable scaffolds and durable functional coating materials.
Long-Term Implantable Biomedical Research: Widely used in ultra-long-cycle biological tracking, persistent biomolecule immobilization, long-term targeted therapy and high-durability functional biomaterial development.
Storage and Handling
Storage: Store at –20 °C in a sealed, dry, moisture-proof container. Inert gas sealing is strongly recommended for long-term storage to preserve dual-biotin biological activity and polymer structural integrity.
Handling: Avoid moisture intrusion, repeated freeze-thaw cycles and high-temperature environments to prevent polymer chain hydrolysis and irreversible biotin activity attenuation.
PLGA-di-Biotin, MW 20K is an ultra-high-stability dual-biotin functionalized PLGA copolymer with tunable multi ratios and customizable molecular weight, professionally developed for high-density biotin-avidin crosslinking, ultra-long-cycle sustained targeted drug delivery and durable advanced biomaterial research.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.