PLGA-di-Biotin is a high-performance dual-biotin functionalized biodegradable PLGA copolymer developed for ultra-high-affinity biotin-avidin conjugation, multi-site biomolecular coupling, and high-stability targeted drug delivery research. It supports multiple optional lactide-glycolide ratios and custom formulation services, providing dual-terminal biotin binding sites for stronger and more stable biological modification compared to single-biotin PLGA materials.
Basic Specifications
Polymer Composition: Poly(D,L-lactide-co-glycolic acid)-di-Biotin
Lactide:Glycolide Ratio: 50:50, 65:35, 75:25, 85:15, Custom
Key Features and Benefits
Dual-Biotin Terminal Functionalization: Features biotin capping on both polymer terminals, providing double binding sites for avidin/streptavidin. Significantly improves conjugation efficiency, binding stability and cross-linking ability compared with conventional single-biotin PLGA, enabling robust and durable bioconjugation systems.
Multi-Ratio Tunable Formulation: Available in mainstream 50:50, 65:35, 75:25, 85:15 ratios and fully customized proportions. Precisely regulates polymer hydrophilicity, degradation rate, flexibility and particle morphology to meet rapid, medium and long-term release experimental requirements.
Biocompatible & Fully Biodegradable: Possesses excellent biosafety, gradually hydrolyzing into natural lactic acid and glycolic acid under physiological conditions. No toxic residues or inflammatory reactions, suitable for in vitro experiments and in vivo biomedical applications.
High Cross-Linking & Targeting Stability: The dual-biotin structure enhances polymer cross-linking capability and carrier surface functional density, effectively improving targeted recognition accuracy and long-term binding stability of drug delivery systems.
Versatile Molecular Adaptability: Compatible with multiple custom molecular weight specifications, adaptable for nanoparticle fabrication, hydrogel cross-linking, and functional biomaterial construction.
Applications
High-Stability Biotin-Avidin Bioconjugation: Ideal for high-efficiency coupling with streptavidin-modified antibodies, proteins, probes and ligands, supporting high-stability biological labeling and targeted modification.
Enhanced Targeted Drug Delivery: Dual-biotin active sites significantly improve the targeting binding ability of PLGA nanoparticles and microspheres, optimizing the enrichment efficiency of targeted drug delivery systems.
Biomaterial Cross-Linking & Functionalization: Serves as a dual-functional cross-linking monomer for constructing biotin-functionalized hydrogels, biodegradable scaffolds and high-stability coating materials.
Advanced Biomedical Research: Widely used in precise biological recognition, multi-point immobilization of biomolecules, and long-term stable targeted therapy and bioimaging research.
Storage and Handling
Storage: Store at –20 °C in a sealed, dry, moisture-proof container. Inert gas sealing is recommended for long-term storage to maintain biotin activity and polymer integrity.
Handling: Avoid moisture invasion, repeated freeze-thaw cycles and excessive heat to prevent polymer hydrolysis and biotin activity attenuation.
PLGA-di-Biotin is a dual-biotin functionalized biodegradable PLGA copolymer with tunable lactide-glycolide ratios, integrating dual-site high-affinity bioconjugation performance and excellent degradability for high-stability biotin-avidin coupling, enhanced targeted drug delivery and advanced functional biomaterial development.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.