PLGA-di-Biotin, MW 10K is a high-molecular-weight dual-biotin functionalized biodegradable PLGA copolymer, featuring dual-terminal biotin modification for ultra-high-affinity biotin-avidin crosslinking and stable targeted drug delivery. With tunable multi lactide-glycolide ratios and customizable formulation options, this 10K grade polymer balances excellent structural stability and moderate long-cycle degradation performance, ideal for advanced nanoparticle modification, biomaterial crosslinking and long-term biomedical targeting research.
Basic Specifications
Polymer Composition: Poly(D,L-lactide-co-glycolic acid)-di-Biotin
Lactide:Glycolide Ratio: 50:50, 65:35, 75:25, 85:15, Custom
Molecular Weight: 10K, Custom
Key Features and Benefits
Dual-Biotin Terminal Functionalization: Dual-end biotin capping provides double independent biotin binding sites, delivering significantly higher avidin/streptavidin conjugation efficiency, binding density and structural stability compared to single-biotin PLGA. It supports robust multi-point biomolecule immobilization and durable surface functionalization for long-term biological systems.
Multi-Ratio Tunable Formulation: Covers mainstream 50:50, 65:35, 75:25, 85:15 and fully custom lactide-glycolide ratios. Precise ratio adjustment flexibly regulates polymer hydrophobicity, mechanical strength and degradation cycle, perfectly matching medium and long-term sustained-release formulation requirements.
Stable 10K Molecular Weight Performance: High 10K molecular weight forms dense polymer chain entanglement, offering superior particle structural rigidity and anti-deformation ability relative to low and medium MW PLGA. It ensures stable formulation morphology and moderate, uniform long-cycle degradation without premature drug leakage.
Excellent Biocompatibility & Biodegradability: Fully biocompatible and biosafe under physiological conditions, gradually hydrolyzing into non-toxic lactic acid and glycolic acid. No inflammatory stimulation or residual toxicity, suitable for in vitro bioconjugation experiments and long-term in vivo biomedical applications.
Enhanced Cross-Linking & Targeting Stability: Dual-biotin active sites effectively improve polymer crosslinking density and carrier surface functional activity, greatly enhancing targeted recognition accuracy, biological binding stability and sustained delivery performance of drug delivery systems.
Applications
High-Stability Biotin-Avidin Bioconjugation: Optimized for high-efficiency, multi-point coupling with streptavidin-labeled antibodies, functional proteins, fluorescent probes and targeted ligands for stable biological labeling and modification.
Long-Cycle Targeted Drug Delivery: Ideal for preparing structurally stable PLGA nanoparticles and microspheres, enabling long-term sustained release and high-precision targeted enrichment for chronic disease treatment formulations.
Biomaterial Cross-Linking & Functionalization: Acts as a high-performance dual-functional crosslinker for constructing biotin-modified hydrogels, biodegradable scaffolds and stable functional coating materials.
Advanced Long-Term Biomedical Research: Widely applied in long-cycle biological tracking, persistent biomolecule immobilization, stable targeted therapy and advanced functional biomaterial development.
Storage and Handling
Storage: Store at –20 °C in a sealed, dry, moisture-proof container. Inert gas sealing is recommended for long-term storage to protect dual-biotin activity and polymer structural integrity.
Handling: Avoid moisture intrusion, repeated freeze-thaw cycles and excessive heat exposure to prevent polymer hydrolysis and biotin activity attenuation.
PLGA-di-Biotin, MW 10K is a high-stability dual-biotin functionalized PLGA copolymer with tunable lactide-glycolide ratios and customizable molecular weight, specially designed for high-efficiency biotin-avidin crosslinking, long-cycle sustained targeted drug delivery and advanced functional biomaterial research.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.