PLGA-di-Biotin, MW 10K is a biotin-functionalized poly(lactic-co-glycolic acid) with biotin groups at both polymer ends. The biodegradable PLGA backbone specifically supports affinity binding, bioconjugation, nanoparticle functionalization, and biomaterial research.
Key Features and Benefits
- Di-Biotin-Functionalized PLGA: Features biotin groups at both ends of the biodegradable PLGA chain for affinity-based interactions.
- MW 10K: Provides a moderate molecular weight with good processability specifically for particle formulation, polymer functionalization, and biomaterial research.
- Dual Biotin Functionality: Two terminal biotin groups provide binding sites specifically for avidin, streptavidin, and related biotin-binding proteins.
- High-Affinity Recognition: Biotin provides strong, specific noncovalent interactions with avidin and streptavidin.
- Biodegradable Copolymer: The PLGA backbone contains hydrolyzable ester linkages that specifically support gradual degradation under appropriate conditions.
- Lactide-Glycolide Backbone: Combines lactic acid- and glycolic acid-derived units in a biodegradable polyester platform.
- Difunctional Polymer Platform: Dual biotin groups support affinity-mediated assembly, immobilization, bridging, and polymer functionalization.
Applications
- Avidin-Biotin Binding: Supports high-affinity interactions with avidin, streptavidin, and related biotin-binding proteins.
- Affinity-Based Assembly: Enables noncovalent assembly with compatible avidin- or streptavidin-containing components.
- Bioconjugation: Supports affinity-based association with biotin-binding proteins and other compatible functional systems.
- Nanoparticle Functionalization: Enables affinity-based modification and assembly of PLGA nanoparticles and related polymeric systems.
- Surface Modification: Supports immobilization of PLGA materials on compatible avidin- or streptavidin-functionalized surfaces.
- Affinity Capture: Enables development of biotin-mediated capture, immobilization, and recognition systems.
- Drug Delivery: Supports functional biodegradable polymer systems for drug-delivery and controlled-release research.
- Biomaterial Research: Supports development of biotin-functionalized polymers, particles, coatings, composites, and related biomaterials.
Storage and Handling
- Storage: Store at –20 °C in a tightly sealed container under dry conditions.
- Handling: Protect from moisture and excessive heat. Allow the material to reach room temperature before opening to minimize condensation.
PLGA-di-Biotin, MW 10K provides a biodegradable PLGA platform with dual terminal biotin functionality and specifically supports avidin-biotin binding, affinity assembly, nanoparticle functionalization, surface modification, drug-delivery research, and biomaterial development.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.