PLGA-di-Biotin, MW 40K is a biotin-functionalized poly(lactic-co-glycolic acid) with a molecular weight of approximately 40K and biotin groups at both polymer chain ends. It combines a biodegradable PLGA backbone with dual biotin functionality specifically for avidin-biotin binding, affinity-based assembly, bioconjugation, nanoparticle functionalization, and biomaterial research.
Key Features and Benefits
- Di-Biotin-Functionalized PLGA: Features biotin functionality at both ends of the biodegradable poly(lactic-co-glycolic acid) chain for multivalent affinity-based interactions.
- MW 40K: Provides a relatively high molecular weight specifically for polymer matrix formation, particle formulation, controlled-release research, and functional biomaterial development.
- Dual Biotin Functionality: Two terminal biotin groups provide affinity-binding sites specifically for avidin, streptavidin, and related biotin-binding proteins.
- High-Affinity Recognition: Biotin supports strong, specific noncovalent interactions with avidin and streptavidin for affinity-based assembly and functionalization.
- Biodegradable Copolymer: The PLGA backbone contains hydrolyzable ester linkages that specifically support gradual polymer degradation under appropriate conditions.
- Lactide-Glycolide Backbone: Combines lactic acid- and glycolic acid-derived units in a biodegradable polyester platform for polymer and drug-delivery research.
- Difunctional Polymer Platform: Biotin groups at both chain ends support affinity-mediated bridging, assembly, immobilization, and development of more complex functional polymer systems.
Applications
- Avidin-Biotin Binding: Supports high-affinity interaction with avidin, streptavidin, and related biotin-binding proteins.
- Affinity-Based Assembly: Enables noncovalent assembly of PLGA with compatible avidin- or streptavidin-containing components.
- Bioconjugation: Supports affinity-based association with biotin-binding proteins and related functional systems.
- Nanoparticle Functionalization: Enables affinity-based modification and assembly of PLGA nanoparticles and related polymeric delivery systems.
- Surface Modification: Supports immobilization and organization of PLGA-containing materials on compatible avidin- or streptavidin-functionalized surfaces.
- Affinity Capture: Enables development of biotin-mediated capture, immobilization, and recognition systems.
- Drug Delivery: Supports development of functional biodegradable polymer systems for drug-delivery and controlled-release research.
- Biomaterial Research: Supports development of biotin-functionalized biodegradable polymers, particles, coatings, composites, and related biomaterials.
Storage and Handling
- Storage: Store at –20 °C in a tightly sealed container under dry conditions.
- Handling: Protect from moisture and excessive heat. Allow the material to equilibrate to room temperature before opening to minimize moisture condensation.
PLGA-di-Biotin, MW 40K provides a biodegradable PLGA platform with dual terminal biotin functionality for high-affinity avidin-biotin interactions. It specifically supports affinity-based assembly, bioconjugation, nanoparticle functionalization, surface modification, drug-delivery research, and functional biomaterial development.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.