PLGA-di-Biotin, MW 40K is an ultra-high-molecular-weight, top-tier dual-biotin functionalized biodegradable PLGA copolymer in the di-biotin series. Featuring extreme mechanical rigidity, maximum structural integrity and multi-year ultra-slow degradability, this dual-terminal biotin-modified polymer delivers ultra-high-density biotin-avidin crosslinking and permanent long-term targeting stability. It supports full tunable lactide-glycolide ratios and custom formulation services, exclusively optimized for implantable biomaterials, multi-year sustained drug delivery and high-standard long-cycle biomedical research.
Basic Specifications
Polymer Composition: Poly(D,L-lactide-co-glycolic acid)-di-Biotin
Lactide:Glycolide Ratio: 50:50, 65:35, 75:25, 85:15, Custom
Molecular Weight: 40K, Custom
Key Features and Benefits
Dual-Biotin Terminal Functionalization: Dual-end biotin capping provides dual independent high-affinity binding sites, achieving maximum conjugation density and crosslinking strength compared to single-biotin and lower-MW di-biotin PLGA. It maintains stable biotin activity throughout multi-year polymer degradation, supporting permanent multi-point biomolecule immobilization and long-term in vivo surface functionalization.
Multi-Ratio Tunable Formulation: Covers standard 50:50, 65:35, 75:25, 85:15 and fully customized lactide-glycolide ratios. Precise ratio modulation accurately tailors polymer hydrophobicity, ultra-high mechanical toughness and multi-year degradation kinetics, meeting rigorous requirements of long-acting implantable formulations and chronic disease treatment systems.
Premium 40K Ultra-High MW Performance: As the highest molecular weight grade in the series, 40K PLGA forms extremely dense polymer chain entanglement, delivering industry-leading structural rigidity, anti-fatigue performance and zero-deformation stability. It features the longest degradation cycle among all di-biotin PLGA variants, completely eliminating particle rupture, structural failure and premature drug leakage for multi-year ultra-long-release systems.
Superior Biocompatibility & Mild Degradation: Possesses premium physiological biosafety with mild, uniform hydrolytic degradation into non-toxic lactic acid and glycolic acid. The slow degradation process avoids local inflammation, tissue irritation and toxic residue, fully compliant with strict standards for long-term implantation and clinical translational research.
Max Cross-Linking & Permanent Targeting Stability: Dual-biotin active sites maximize polymer crosslinking density and surface functional activity, endowing drug carriers and biomaterials with ultra-durable structural stability and persistent targeted recognition capability, ideal for multi-year long-term targeted therapy and implantable material construction.
Applications
Permanent High-Density Biotin-Avidin Bioconjugation: Optimized for ultra-stable multi-point coupling with streptavidin-modified antibodies, therapeutic proteins, biological probes and targeted ligands, supporting long-term persistent biological labeling and modification.
Multi-Year Ultra-Long Sustained Drug Delivery: Specially designed for implantable long-acting drug delivery systems and multi-year controlled-release formulations, solving the limited release cycle of lower-molecular PLGA materials for chronic disease long-term treatment.
High-Durability Implantable Biomaterial Functionalization: Acts as a high-end dual-functional crosslinker for fabricating long-term implantable scaffolds, ultra-stable biotin-modified hydrogels and durable biomedical coating materials.
Long-Cycle Clinical & Translational Research: Widely applied in multi-year in vivo biological tracking, permanent biomolecule immobilization, ultra-long targeted therapy and high-performance durable functional biomaterial development.
Storage and Handling
Storage: Store at –20 °C in a fully sealed, dry, moisture-proof container. Inert gas sealed preservation is highly recommended for long-term inventory to fully retain dual-biotin biological activity and ultra-rigid polymer structural integrity.
Handling: Strictly avoid moisture intrusion, repeated freeze-thaw cycles and high-temperature environments to prevent polymer chain hydrolysis, mechanical performance attenuation and irreversible biotin activity loss.
PLGA-di-Biotin, MW 40K is a top-grade ultra-high-stability dual-biotin functionalized PLGA copolymer with tunable multi ratios and customizable molecular weight, professionally engineered for maximum-density biotin-avidin crosslinking, multi-year ultra-long sustained drug delivery and high-durability implantable advanced biomaterial research.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.