PLGA Biotin Capped, MW 40K is an ultra-high-molecular-weight, high-rigidity biodegradable PLGA copolymer with terminal biotin functionalization, supporting standard lactide-glycolide ratios of 50:50, 75:25, 85:15 and fully custom ratio formulation. As the highest-grade functional PLGA polymer in the series, it delivers exceptional mechanical rigidity, superior structural integrity, and multi-year ultra-slow degradation characteristics, exclusively optimized for long-term implantable devices, multi-year sustained drug release, high-stability bioconjugation, and high-precision advanced biomedical material research.
Key Features and Benefits
Biotin Capped: Features highly stable, activity-retained terminal biotin functional groups, enabling irreversible, ultra-high-affinity specific binding with avidin and streptavidin. It maintains consistent bioconjugation performance throughout the entire ultra-long polymer degradation cycle, supporting permanent surface functionalization and stable biomolecular coupling for long-term in vivo applications.
Lactide Ratio Available: Offers versatile standard ratios including 50:50, 75:25, 85:15 and fully customizable lactide-glycolide proportions. Precise ratio adjustment effectively modulates polymer hydrophobicity, mechanical toughness, and multi-year degradation kinetics, meeting rigorous requirements of long-cycle implantable formulations and chronic disease treatment research.
MW 40K: Represents the maximum molecular weight in the biotin-capped PLGA series with extremely dense polymer chain entanglement and outstanding structural stability. Compared with 2K, 5K, 10K, and 20K PLGA variants, MW 40K exhibits the slowest degradation rate, minimal structural fatigue, zero long-term particle deformation, and excellent film-forming and molding performance, ideal for manufacturing structurally durable long-acting biomedical carriers.
Biocompatible & Biodegradable: Possesses premium biocompatibility and biosafety, gradually hydrolyzing into natural non-toxic lactic acid and glycolic acid under physiological conditions. The mild and slow degradation process avoids local inflammatory reactions, fully compliant with strict safety standards for long-term in vivo implantation and clinical biomedical research.
Premium Functional Polymer Performance: Combines stable biotin targeting functionality with industry-leading mechanical strength and ultra-long degradability. It outperforms lower-molecular PLGA materials in structural durability, formulation stability, and long-term targeting reliability, suitable for high-standard durable biomedical matrix fabrication and precise bioconjugation systems.
Applications
Multi-Year Ultra-Slow Sustained Drug Delivery: Specifically designed for long-cycle chronic disease treatment and multi-year controlled-release drug systems. It completely solves the short release duration and rapid drug burst release defects of low and medium molecular weight PLGA, enabling stable, long-term drug release for up to several years.
Permanent Stable Biotin-Avidin Bioconjugation: Maintains durable biotin activity during long-term in vivo circulation and implantation, achieving stable long-term binding with streptavidin-modified antibodies, targeted probes, therapeutic proteins, and bio-ligands. It is ideal for long-term biomedical targeted imaging, sustained targeted therapy, and biological signal monitoring research.
High-Durability Polymer Functionalization: Serves as a high-end biotin-functionalized PLGA precursor for high-rigidity, long-life biomaterial modification and advanced polymer derivatization, supporting the development of high-stability functional biomedical materials for long-term clinical application.
Ultra-Stable Polymeric Particle & Film Fabrication: The preferred material for preparing ultra-rigid, anti-deformation PLGA nanoparticles, microspheres, and biodegradable functional films. It effectively prevents particle rupture, drug leakage, and structural failure during long-term storage, in vivo circulation, and tissue implantation.
Long-Term Implantable Biomedical Devices: Widely applied in the preparation of implantable biodegradable scaffolds, durable tissue engineering matrices, long-acting medical coatings, and multi-year sustained-release therapeutic implants for advanced regenerative medicine and clinical translational research.
Storage and Handling
Storage: Store at –20 °C in a tightly sealed, dry, moisture-proof container. Inert gas sealed preservation is strongly recommended for long-term inventory storage to fully retain polymer structural rigidity and terminal biotin biological activity.
Handling: Strictly prevent moisture intrusion, repeated freeze-thaw cycles, and high-temperature exposure to avoid polymer chain hydrolysis, mechanical performance attenuation, and irreversible deactivation of terminal biotin functional groups.
PLGA Biotin Capped, MW 40K integrates top-tier ultra-high molecular weight structural durability, tunable multi-ratio multi-year degradability, and stable high-affinity biotin targeting function, specially engineered for multi-year ultra-slow drug delivery, permanent stable bioconjugation, and high-end long-term implantable biomedical material development.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.