PLGA Biotin Capped, MW 5K is a biotin-functionalized poly(lactic-co-glycolic acid) with a terminal biotin group. The biodegradable PLGA backbone specifically supports affinity binding, bioconjugation, nanoparticle functionalization, drug-delivery research, and biomaterial development.
Key Features and Benefits
- Biotin-Capped PLGA: Combines biodegradable PLGA with terminal biotin functionality for affinity-based interactions and functionalization.
- MW 5K: Provides a low molecular weight with good processability specifically for particle formulation, polymer functionalization, and biomaterial research.
- Biotin Functionality: Terminal biotin provides a high-affinity recognition site specifically for avidin, streptavidin, and related biotin-binding proteins.
- High-Affinity Recognition: Biotin forms strong, specific noncovalent interactions with avidin and streptavidin.
- Biodegradable Copolymer: The PLGA backbone contains hydrolyzable ester linkages that specifically support gradual degradation under appropriate conditions.
- Lactide-Glycolide Backbone: Combines lactic acid- and glycolic acid-derived units in a biodegradable polyester platform.
- Good Processability: The low molecular weight facilitates polymer dissolution, formulation, particle preparation, and functionalization.
- Affinity-Based Functionalization: Terminal biotin supports noncovalent attachment of compatible avidin- and streptavidin-containing components.
Applications
- Avidin-Biotin Binding: Supports high-affinity interactions with avidin, streptavidin, and related biotin-binding proteins.
- Affinity-Based Assembly: Enables noncovalent assembly with compatible avidin- or streptavidin-containing components.
- Bioconjugation: Supports affinity-based association with biotin-binding proteins and other compatible functional systems.
- Nanoparticle Functionalization: Enables affinity-based modification of PLGA nanoparticles and related polymeric systems.
- Surface Modification: Supports immobilization of PLGA materials on compatible avidin- or streptavidin-functionalized surfaces.
- Affinity Capture: Enables development of biotin-mediated capture, immobilization, and recognition systems.
- Drug Delivery: Supports functional biodegradable polymer systems for drug-delivery and controlled-release research.
- Biomaterial Research: Supports development of biotin-functionalized polymers, particles, coatings, composites, and related biomaterials.
Storage and Handling
- Storage: Store at –20 °C in a tightly sealed container under dry conditions.
- Handling: Protect from moisture and excessive heat. Allow the material to reach room temperature before opening to minimize condensation.
PLGA Biotin Capped, MW 5K provides a low-molecular-weight biodegradable PLGA platform with terminal biotin functionality and specifically supports avidin-biotin binding, affinity assembly, nanoparticle functionalization, drug-delivery research, and biomaterial development.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.