PLGA Biotin Capped, MW 20K is a ultra-high-molecular-weight biodegradable PLGA copolymer with terminal biotin functionalization, supporting standard lactide-glycolide ratios of 50:50, 75:25, 85:15 and fully custom ratio customization. As the high-specification functional PLGA polymer, it features maximum structural rigidity, superior mechanical strength, and ultra-long degradation cycles, perfectly suited for ultra-long sustained targeted drug delivery, high-stability bioconjugation, high-strength particle fabrication, and advanced implantable biomedical material research.
Key Features and Benefits
Biotin Capped: Possesses active and stable terminal biotin functional groups, enabling ultra-high-specificity and high-affinity binding with avidin and streptavidin. It supports durable, repeatable bioconjugation and surface functional modification without functional group inactivation during long-term material application.
Lactide Ratio Available: Provides multiple optional ratios including 50:50, 75:25, 85:15 and customizable formulations. Different lactide-glycolide proportions can precisely regulate polymer hydrophobicity, mechanical toughness and degradation period to meet ultra-long-cycle biomedical experimental and clinical formulation requirements.
MW 20K: Featuring ultra-high molecular weight, this PLGA polymer has dense polymer chain entanglement, outstanding mechanical stability and structural toughness. Compared with 2K, 5K and 10K low/medium/high MW PLGA, it achieves the longest in-vivo degradation cycle and minimal particle swelling deformation, maintaining complete structural stability for long-term sustained release systems.
Biocompatible & Biodegradable: Strictly biocompatible and low-toxic polymer material, which can be completely hydrolyzed into endogenous lactic acid and glycolic acid in physiological environments. It has excellent biosafety for long-term in vitro experiments and in vivo implantable biomedical applications.
Highly Versatile Functional Polymer: Integrates biotin active targeting performance and ultra-high mechanical properties, uniquely applicable to high-stability micro-nano particles, long-acting biodegradable coatings, high-toughness tissue engineering scaffolds and durable implantable polymer matrices.
Applications
Ultra-Long-Term Sustained Drug Delivery: Specially developed for ultra-long-cycle slow-release drug delivery systems, solving the problem of rapid drug release and short efficacy cycle of low-molecular PLGA materials, suitable for long-term disease treatment and controlled-release drug research.
High-Stability Biotin-Avidin Bioconjugation: Stable terminal biotin activity ensures long-term effective binding with streptavidin-labeled antibodies, bio-probes, functional proteins and targeted ligands, supporting high-precision and long-term biomedical targeted recognition and detection.
High-Toughness Polymer Derivatization: Serves as a high-performance biotin-functionalized PLGA building block for high-strength biomaterial modification and advanced polymer functional derivatization, meeting the preparation needs of high-stability biomedical materials.
High-Strength Particle Fabrication: Ideal raw material for preparing high-rigidity, deformation-resistant PLGA nanoparticles and microspheres, effectively avoiding particle rupture, drug leakage and structural failure during long-term storage and in-vivo circulation.
Implantable Biomedical Biomaterials: Widely used in the preparation of implantable biodegradable scaffolds, long-acting functional coatings, durable tissue engineering materials and ultra-slow-release therapeutic carriers for advanced biomedical research.
Storage and Handling
Storage: Store at –20 °C in a fully sealed, dry and moisture-proof container; inert gas sealed storage is highly recommended for long-term stock preservation to protect polymer structural stability and terminal biotin activity.
Handling: Strictly avoid moisture invasion, repeated freeze-thaw cycles and high-temperature environment, so as to prevent polymer chain hydrolysis, structural toughness decline and irreversible inactivation of biotin functional groups.
PLGA Biotin Capped, MW 20K integrates ultra-high molecular weight mechanical stability, tunable multi-ratio long-term degradability and high-specificity biotin targeting function, which is professionally customized for ultra-long sustained drug delivery, high-stability bioconjugation and high-toughness implantable biomaterial development.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.