DBCO-NH-PEG5-NHS ester CAS:1378531-80-6 is the DBCO NHS ester contains an NHS ester functional group (-NHS) attached to the end of a PEG chain, and a DBCO group (dibenzocyclooctyne) attached to the other end of the PEG chain via a linker. The NHS ester is known for its ability to react with primary amine groups (-NH2) of biomolecules, while the DBCO group is known for its ability to react with azide functional groups (-N3) of biomolecules.
DBCO-NH-PEG5-NHS ester has been widely used in the development of novel drug delivery systems and bioconjugation strategies. Its unique chemical properties allow for the covalent attachment of biomolecules, such as peptides, proteins, and antibodies, to various surfaces, such as nanoparticles, micelles, and hydrogels, via bioorthogonal click chemistry. This approach offers many advantages, such as high selectivity, fast reaction kinetics, and minimal interference with biological processes, leading to improved therapeutic efficacy and reduced side effects.
In addition to its use in drug delivery systems, DBCO-NH-PEG5-NHS ester has also been employed in the development of various diagnostic and imaging tools, such as biosensors and contrast agents. Its ability to selectively label biomolecules with high efficiency and specificity has opened new avenues for the detection and monitoring of diseases and biological processes.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
