DBCO-NH-PEG4-amine
This product is a heterobifunctional PEG linker containing a dibenzocyclooctyne (DBCO) group, a PEG4 spacer, and a free amine. It specifically enables copper-free click chemistry with azides and amide coupling, offering solubility and orthogonal reactivity.
Key Features and Benefits
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DBCO Group: Reacts rapidly with azides via strain-promoted azide–alkyne cycloaddition (SPAAC).
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Primary Amine: Couples with carboxyls, NHS esters, or activated linkers.
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PEG4 Spacer: Enhances solubility and provides moderate chain length.
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Dual Reactivity: Combines copper-free click chemistry with amine conjugation.
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High Purity: Ensures reproducibility in sensitive bioconjugation workflows.
Applications
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Bioconjugation: Links azide-modified biomolecules with amine-reactive partners.
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Probe Development: Builds multifunctional probes for imaging and diagnostics.
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Drug Delivery: Provides PEG scaffolds with orthogonal reactive groups.
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Material Science: Functionalizes nanoparticles, surfaces, and polymers with dual chemistry.
Storage and Handling
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Storage: Store at –20 °C in a sealed, light- and moisture-protected container.
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Handling: Use anhydrous solvents such as DMF or DMSO; avoid prolonged exposure to moisture.
This product integrates copper-free click chemistry with amine reactivity in a PEG4 scaffold, specifically providing a soluble and versatile linker.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
