DSPE‑PEG‑NHS, MW 10000
DSPE‑PEG‑NHS (MW 10000) (full name: 1,2‑distearoyl‑sn‑glycero‑3‑phosphoethanolamine‑N‑[polyethylene glycol‑10000]‑succinimidyl ester, abbreviated as DSPE‑PEG10k‑NHS) is a highly functional, amphiphilic phospholipid‑PEG conjugate.
Core Structure
- Hydrophobic domain: DSPE (1,2‑distearoyl‑sn‑glycero‑3‑phosphoethanolamine), a saturated C18 phospholipid that stably inserts into lipid bilayers.
- Hydrophilic spacer: A long PEG‑10000 chain, providing exceptional water solubility, strong steric stabilization, and stealth properties.
- Reactive end: A succinimidyl ester (NHS) group, which reacts efficiently with primary amines (-NH₂) under mild, slightly basic conditions (pH 8–10).
Key Properties
- Appearance: White to off‑white solid/powder.
- Solubility: Soluble in organic solvents (DMSO, DMF, chloroform) and readily dispersible in aqueous solutions.
- Purity: Typically ≥95%.
- Storage: −20 °C, desiccated, protected from light; avoid repeated freeze‑thaw cycles.
Main Applications
- Liposome & Nanoparticle PEGylation: Inserts into lipid membranes to form a dense hydration layer, significantly reducing non‑specific protein adsorption and prolonging in vivo circulation time.
- Targeted Delivery: The NHS group enables covalent conjugation to amine‑containing molecules (antibodies, peptides, proteins, ligands) for precise targeting.
- Surface Functionalization: Used to modify lipid‑based nanocarriers, micelles, and biomaterial surfaces for drug delivery and biomedical research.
- Bioconjugation: Serves as a versatile linker for attaching biomolecules to lipid assemblies.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
