Bis-PEG4-acid (CAS: 31127-85-2)
Key Features:
- Bifunctional PEG Derivative: Contains two terminal carboxylic acid (COOH) groups for versatile conjugation.
- Amide Bond Formation: The terminal carboxylic acids can react with primary and secondary amine groups in the presence of coupling reagents such as EDC, DCC, and HATU to form a stable amide bond.
- Sequential Conjugation: Enables the controlled conjugation of two different amine-bearing biomolecules when used sequentially.
- PEG4 Spacer: Enhances solubility and flexibility, minimizing steric hindrance during bioconjugation and increasing the aqueous solubility of resulting conjugates.
- High Stability: Provides reliable and robust conjugation for various applications.
Applications:
- Antibody-Drug Conjugates (ADCs): Used in developing ADCs for targeted therapeutic delivery.
- Protein Modification: Facilitates the attachment and modification of proteins for research and therapeutic uses.
- Bioconjugation Studies: Suitable for linking biomolecules in complex biological assays.
- Drug Development: Supports the synthesis of stable bioconjugates for targeted drug delivery systems.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
