Biotin-PEG4-methyltetrazine
This product is a multifunctional PEG linker containing a biotin group, a PEG4 spacer, and a methyltetrazine moiety. It enables high-affinity biotin–streptavidin binding and rapid inverse-electron-demand Diels–Alder (IEDDA) click chemistry with trans-cyclooctene (TCO), making it ideal for dual bioconjugation strategies.
Key Features and Benefits
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Biotin Moiety: Provides strong binding affinity to streptavidin and avidin systems.
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Methyltetrazine Group: Reacts rapidly with TCO in bioorthogonal click chemistry.
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PEG4 Spacer: Enhances solubility and minimizes steric hindrance.
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Dual Reactivity: Combines affinity binding with tetrazine click chemistry.
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High Purity: Ensures reliable performance in sensitive applications.
Applications
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Bioconjugation: Links biotin-binding systems with TCO-modified biomolecules.
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Probe Development: Builds multifunctional probes for imaging and diagnostics.
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Drug Delivery: Provides PEGylated scaffolds with orthogonal reactivity.
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Material Science: Functionalizes polymers and nanoparticles with dual chemistry.
Storage and Handling
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Storage: Keep at –20 °C in a sealed, light- and moisture-protected container.
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Handling: Use anhydrous solvents such as DMF or DMSO to maintain reactivity.
This product integrates biotin–streptavidin affinity with tetrazine–TCO click reactivity in a PEG4 scaffold, specifically offering a versatile linker for advanced bioconjugation and probe development.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
