4-[3-(Trifluoromethyl)-3H-diazirin-3-yl]benzoic acid

4-[3-(Trifluoromethyl)-3H-diazirin-3-yl]benzoic acid

This product is a photoreactive diazirine compound featuring a trifluoromethyl diazirinyl group on a benzoic acid scaffold. Upon UV activation, the diazirine generates highly reactive carbene species for covalent labeling. The carboxylic acid functionality specifically enables bioconjugation and further derivatization.

Key Features and Benefits

• Diazirine Photoreactivity: Generates carbene intermediates upon UV irradiation for covalent labeling.

• Trifluoromethyl Substitution: Enhances photostability and efficient carbene generation.

• Benzoic Acid Scaffold: Provides rigidity and stability for probe design and functionalization.

• Carboxylic Acid Group: Enables amide bond formation with amines for bioconjugation.

• High Purity: Manufactured to ≥95% purity for consistent and reproducible results.

Applications

• Photoaffinity Labeling: Identifies protein–ligand interactions through covalent crosslinking.

• Probe Development: Builds photoreactive probes for chemical biology and target identification.

• Material Science: Introduces covalent crosslinking points into polymers and networks.

• Organic Synthesis: Serves as a versatile intermediate for diazirine-containing building blocks.

Storage and Handling

• Storage: Keep at –20 °C in a sealed, light-protected container.

• Handling: Minimize exposure to light; handle under dim or red light when possible. Avoid prolonged heat.

This product combines diazirine photoreactivity with carboxylic acid functionality, making it an especially powerful building block for photo-crosslinking and probe development.

AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.