Propargyl-PEG4-bromide
This product is a PEG linker containing a terminal propargyl group, a PEG4 spacer, and a reactive bromide. It specifically enables copper-catalyzed or copper-free click chemistry with azides and alkylation-based substitution through the bromide functionality.
Key Features and Benefits
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Propargyl Group: Supports CuAAC or SPAAC click chemistry with azides.
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Bromide Group: Acts as a reactive handle for nucleophilic substitution.
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PEG4 Spacer: Enhances solubility and reduces steric hindrance.
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Dual Reactivity: Combines click chemistry with alkylation potential.
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High Purity: Ensures reproducible results in bioconjugation workflows.
Applications
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Bioconjugation: Links azide- and nucleophile-containing biomolecules.
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Probe Development: Builds multifunctional probes for diagnostics and imaging.
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Drug Delivery: Provides PEGylated scaffolds with dual reactivity.
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Organic Synthesis: Serves as a versatile intermediate for custom linker design.
Storage and Handling
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Storage: Store at –20 °C in a sealed, light- and moisture-protected container.
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Handling: Use anhydrous solvents such as DMF or DMSO; avoid prolonged exposure to moisture.
This product integrates alkyne click reactivity with a reactive bromide in a PEG4 scaffold, specifically offering versatility for synthesis and conjugation.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
