Tetrazine-PEG5-NHS ester
This product is a bifunctional PEG linker containing a tetrazine group, a PEG5 spacer, and an N-hydroxysuccinimide (NHS) ester. It enables rapid inverse-electron-demand Diels–Alder (IEDDA) click chemistry with trans-cyclooctene (TCO) and efficient amine conjugation, making it especially versatile for dual bioconjugation.
Key Features and Benefits
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Tetrazine Group: Reacts rapidly with TCO in bioorthogonal click chemistry.
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NHS Ester: Couples efficiently with primary amines to form stable amide bonds.
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PEG5 Spacer: Provides solubility and reduces steric hindrance.
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Dual Reactivity: Combines tetrazine–TCO click chemistry with amine conjugation.
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High Purity: Ensures reproducibility in sensitive workflows.
Applications
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Bioconjugation: Links TCO-modified and amine-containing biomolecules.
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Probe Development: Builds multifunctional probes for diagnostics and imaging.
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Drug Delivery: Provides PEGylated scaffolds with orthogonal conjugation handles.
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Material Science: Functionalizes polymers and nanoparticles with dual reactivity.
Storage and Handling
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Storage: Keep at –20 °C in a sealed, light- and moisture-protected container.
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Handling: Use anhydrous solvents such as DMF or DMSO to maintain reactivity.
This product integrates tetrazine click reactivity with NHS ester amine coupling in a PEG5 scaffold, specifically providing a powerful tool for multifunctional conjugation strategies.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
