Tetrazine-PEG4-OTs is a dual-functional reagent featuring a tetrazine group for rapid, bioorthogonal IEDDA reactions with strained alkenes (e.g., TCO, norbornene, cyclopropene) and a tosyl group for versatile nucleophilic substitution. The tetrazine forms a stable dihydropyridazine linkage with exceptional speed and selectivity, enabling efficient conjugation in complex environments, including living systems. Its PEG4 spacer ensures solubility and reduces steric hindrance.
Features
- Tetrazine Group: Rapid, selective IEDDA reactions for robust conjugation.
- Tosyl Group: Versatile for nucleophilic substitution chemistry.
- PEG4 Spacer: Enhances solubility and accessibility.
- Biocompatibility: Ideal for use in biological and chemical systems.
- High Purity: ≥95% for reliable results.
Applications
- Bioconjugation: Site-specific modification of biomolecules.
- Imaging: Development of fluorescent, PET, and SPECT probes.
- Diagnostics: Functionalization for biosensors and assays.
- Therapeutics: Drug delivery and radionuclide therapies.
- Material Science: Synthesis of hydrogels and functional polymers.
- Chemical Biology: Studies in complex and live biological systems.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
