TCO-PEG9-maleimide
This product is a bifunctional PEG9 linker with a trans-cyclooctene (TCO) for rapid tetrazine click chemistry and a maleimide group for thiol-specific conjugation. The PEG9 spacer provides hydrophilicity, flexibility, and reduced steric hindrance, making it especially ideal for orthogonal bioconjugation and drug delivery strategies.
Key Features and Benefits:
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TCO Group: Enables fast, bioorthogonal IEDDA click chemistry with tetrazines.
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Maleimide Group: Selectively conjugates with thiol groups in proteins or peptides.
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PEG9 Spacer: Enhances solubility and accessibility of reactive groups.
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High Purity: Ensures reproducibility in sensitive bioconjugation workflows.
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Dual Reactivity: Supports orthogonal and stepwise conjugation approaches.
Applications:
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Bioconjugation: Dual reactivity for combining thiol and tetrazine chemistry.
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Drug Delivery: Useful in linker-payload designs for targeted therapeutics.
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Antibody-Drug Conjugates (ADCs): Enables precise conjugation strategies.
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Surface Functionalization: Modify nanoparticles, hydrogels, or polymers.
Storage and Handling:
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Storage: Store at –20 °C, protected from moisture and light.
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Handling: Use anhydrous solvents (e.g., DMSO, DMF) to preserve maleimide and TCO stability.
This product provides orthogonal thiol and click-reactive handles with a hydrophilic PEG spacer, making it an especially versatile linker for advanced conjugation workflows.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
