TCO-PEG4-maleimide
This product is a heterobifunctional linker with a trans-cyclooctene (TCO) for rapid tetrazine ligation and a maleimide for thiol conjugation. The PEG4 spacer provides solubility, flexibility, and spacing, making it especially useful for bioorthogonal labeling, ADC design, and targeted bioconjugation.
Key Features and Benefits:
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TCO Group: Enables ultrafast IEDDA click reactions with tetrazines.
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Maleimide Group: Selectively couples with thiols for stable cysteine conjugation.
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PEG4 Spacer: Enhances hydrophilicity, reduces steric hindrance, and improves accessibility.
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Dual Reactivity: Combines bioorthogonal ligation with thiol conjugation.
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High Purity: Ensures reproducibility in research and therapeutic workflows.
Applications:
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ADC Linker Design: Combines thiol-reactivity and click chemistry for dual-functional conjugates.
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Bioorthogonal Labeling: Supports ultrafast TCO–tetrazine ligation in vitro and in vivo.
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Bioconjugation: Couples thiol-containing biomolecules with tetrazine-modified partners.
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Probe Development: Builds multifunctional imaging and diagnostic probes.
Storage and Handling:
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Storage: Store at –20 °C in a tightly sealed, moisture- and light-protected container.
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Handling: Use anhydrous solvents (e.g., DMF, DMSO); avoid prolonged exposure to light to preserve TCO activity.
This product integrates ultrafast click chemistry with thiol conjugation in a PEG4 scaffold, making it an especially versatile reagent for advanced conjugation and therapeutic applications.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
