TCO-PEG3-oxyamineBoc
This product is a high-purity heterobifunctional linker featuring a trans-cyclooctene (TCO) group for rapid bioorthogonal click reactions and a Boc-protected oxyamine for selective deprotection and further conjugation. The PEG3 spacer enhances solubility, flexibility, and accessibility in conjugation systems.
Key Features and Benefits
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TCO Moiety – Enables fast and efficient inverse-electron-demand Diels–Alder (IEDDA) reactions with tetrazines.
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Boc-Protected Oxyamine – Provides a stable masked reactive site, unmasked upon deprotection for conjugation with aldehydes or ketones.
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PEG3 Spacer – Improves water solubility, reduces steric hindrance, and increases linker flexibility.
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High Purity – Suitable for bioconjugation, probe development, and drug delivery.
Applications
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Bioorthogonal labeling via TCO–tetrazine click chemistry
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Conjugation to aldehyde- or ketone-containing biomolecules after Boc removal
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Development of imaging probes and therapeutic conjugates
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Spacer/linker for drug delivery and diagnostics
Storage & Handling
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Storage: Store at –20 °C, dry, and protected from light.
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Use: Dissolve in anhydrous solvents (e.g., DMSO, DMF). Avoid repeated freeze–thaw cycles.
This product offers a TCO group for fast bioorthogonal conjugation and a Boc-protected oxyamine for selective carbonyl coupling, with a PEG3 spacer specifically for solubility and flexibility.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
