TCO-PEG1-maleimide
This product is a heterobifunctional linker featuring a trans-cyclooctene (TCO) group for ultrafast tetrazine ligation and a maleimide group for selective thiol conjugation. The PEG1 spacer provides hydrophilicity and compact flexibility, making it especially useful for dual-functional bioconjugation, probe development, and drug delivery.
Key Features and Benefits:
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TCO Group: Enables ultrafast IEDDA ligation with tetrazines.
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Maleimide Group: Selectively reacts with thiols to form stable thioether bonds.
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PEG1 Spacer: Provides solubility and minimal steric hindrance.
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Dual Reactivity: Combines bioorthogonal and thiol-targeted conjugation.
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High Purity: Ensures reproducibility in sensitive workflows.
Applications:
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Bioconjugation: Links thiol- and tetrazine-functional biomolecules.
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Probe Development: Builds multifunctional probes for imaging and diagnostics.
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Drug Delivery: Supports PEGylated scaffolds with orthogonal handles.
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Synthetic Chemistry: Useful in stepwise and multifunctional linker design.
Storage and Handling:
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Storage: Store at –20 °C in a sealed, light- and moisture-protected container.
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Handling: Use anhydrous solvents (e.g., DMF, DMSO); avoid maleimide hydrolysis.
This product combines ultrafast tetrazine reactivity with thiol-selective conjugation in a compact PEG1 scaffold, specifically offering solubility and versatility for advanced bioconjugation.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
