tBu-ester-PEG2-BocNH Tyrosine Methyl Ester
This product is a multifunctional protected amino acid derivative containing a tert-butyl ester, PEG2 spacer, Boc-protected amine, and tyrosine methyl ester. It specifically enables staged deprotection, orthogonal conjugation, and peptide synthesis.
Key Features and Benefits
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t-Butyl Ester: Protects carboxyl functionality for controlled deprotection.
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Boc-Protected Amine: Allows orthogonal removal for selective conjugation.
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Tyrosine Methyl Ester: Preserves aromatic and hydroxyl functionality during synthesis.
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PEG2 Spacer: Enhances solubility and reduces steric hindrance.
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Multifunctional Design: Provides sequential reactivity through staged protecting groups.
Applications
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Peptide Synthesis: Serves as a protected building block for custom peptides.
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Bioconjugation: Offers multiple orthogonal handles for selective conjugation.
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Probe Development: Builds multifunctional probes for chemical biology and diagnostics.
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Drug Discovery: Supports design of protected intermediates in medicinal chemistry.
Storage and Handling
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Storage: Store at –20 °C in a sealed, light- and moisture-protected container.
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Handling: Use anhydrous solvents such as DMF or DMSO; avoid premature hydrolysis or Boc cleavage.
This product integrates multiple protecting groups with a PEG2 spacer, specifically enabling solubility, orthogonality, and versatile staged conjugation strategies.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
