N-oxy-phthalimide-PEG2-bromide CAS:302931-30-2 is a chemical compound that consists of a polyethylene glycol (PEG) chain with an N-oxy-phthalimide (NOP) protecting group and a bromide functional group attached to one end. The NOP protecting group is commonly used in organic synthesis to protect primary amines from unwanted reactions.
N-oxy-phthalimide-PEG2-bromide is used as a linker molecule for the modification of peptides and proteins. The bromide functional group can be used to facilitate the attachment of the NOP-PEG2-bromide to a target molecule through nucleophilic substitution reactions. The NOP protecting group can be removed under basic conditions to expose the free primary amine functional group, which can be further modified to attach other functional groups or molecules.
N-oxy-phthalimide-PEG2-bromide is often used in the development of drug delivery systems, where it can be used to modify drug molecules, peptides, or proteins to increase their solubility, stability, and bioavailability. It can also be used to prepare bioconjugates for diagnostic and therapeutic applications. The PEG chain in N-oxy-phthalimide-PEG2-bromide can impart hydrophilicity and biocompatibility, making it a useful tool in the design of biomaterials.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.