t-Boc-N-Amido-PEG7-CH2CO2-NHS Ester
This product is a high-purity, heterobifunctional PEG linker featuring an NHS ester for efficient amine coupling and a t-Boc-protected amine for controlled, orthogonal conjugation. Additionally, the PEG7 spacer enhances solubility, flexibility, and hydrophilicity, making this reagent ideal for multistep bioconjugation, surface engineering, and targeted drug delivery applications.
Key Features and Benefits:
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NHS Ester Reactivity: Forms stable amide bonds with primary amines under mild, aqueous conditions.
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t-Boc-Protected Amine: Enables selective deprotection for stepwise conjugation strategies.
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PEG7 Spacer: Offers increased hydrophilicity and reduced steric hindrance for improved biocompatibility.
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Heterobifunctional Design: Allows for dual-site functionalization in a sequential manner.
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Versatile Use: Well-suited for therapeutic development, nanoparticle modification, and crosslinking of biomaterials.
Applications:
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Site-Specific Bioconjugation: Enables stepwise assembly of complex biomolecule-drug constructs.
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Surface Modification: Coats nanoparticles, hydrogels, or sensors to introduce reactive or functional handles.
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ADC and Drug Delivery Development: Provides modular control for linker-payload systems in targeted therapy.
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Crosslinking Polymers: Introduces functional groups into PEG-based materials and biomedical scaffolds.
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Diagnostic Assays: Adds flexible PEG spacing between assay components to reduce background interference.
Storage and Handling:
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Storage: Store at -20°C in a dry, dark environment.
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Handling: Use anhydrous organic solvents such as DMSO or DMF. Avoid exposure to moisture to preserve NHS activity.
t-Boc-N-Amido-PEG7-CH2CO2-NHS Ester is a flexible and efficient tool for scientists developing next-generation bioconjugates, targeted delivery systems, and advanced surface coatings. In addition, its protected amine and NHS ester provide orthogonal reactivity for precision chemical engineering.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
