Sulfo-SPDB-DM4 is a DM4 conjugate, commonly used in the development of antibody-drug conjugates (ADCs) for targeted cancer therapy.
Key Features:
- Molecular Formula: C₄₆H₆₃ClN₄O₁₇S₃
- Molecular Weight: 1075.66 g/mol
- DM4 Component: A potent antitubulin agent that disrupts microtubule dynamics, leading to cell cycle arrest and apoptosis in cancer cells.
- Sulfo-SPDB Linker: A water-soluble linker that enhances ADC stability and solubility for efficient antibody conjugation.
Applications:
It is used to synthesize ADCs that deliver cytotoxic drugs directly to cancer cells, reducing systemic toxicity and improving therapeutic outcomes.
Handling and Storage:
- Storage Conditions: Store at -20°C in a dry, light-protected environment.
- Handling Precautions: Use personal protective equipment and ensure proper ventilation during handling.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
