Fmoc-G-amino-CH2O acetyl-Exetecan CAS:1599440-09-1 Exatecan-2-(aminomethoxy)acetamide-Gly-Fmoc is a hexacyclic compound analogous to camptothecin, featuring a glycine linkage and a terminal Fmoc group. This versatile molecule can be employed as a payload in antibody-drug conjugate (ADC) research. Exatecan mesylate acts as a potent inhibitor of DNA topoisomerase I, a critical enzyme in DNA replication, transcription, and recombination. The Fmoc group can be deprotected under basic conditions, exposing the free amine for further conjugations.
Introduction to the application:
In pharmaceutical research and development, Exatecan-2-(aminomethoxy)acetamide-Gly-Fmoc serves as a valuable payload for ADC design. The compound’s topoisomerase I inhibitory activity enhances the therapeutic potential of targeted cancer treatments. By utilizing the Fmoc group, researchers can efficiently deprotect and conjugate Exatecan-2-(aminomethoxy)acetamide-Gly-Fmoc to antibodies or other targeting molecules, creating innovative, more effective anticancer therapeutics.
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