Sulfo DBCO-PEG4-amine
This product is a water-soluble heterobifunctional linker featuring a sulfonated dibenzocyclooctyne (Sulfo-DBCO) for copper-free SPAAC click chemistry and a terminal amine specifically for versatile conjugation. The PEG4 spacer enhances hydrophilicity, flexibility, and steric accessibility, making it especially effective in bioconjugation, probe design, and drug delivery.
Key Features and Benefits:
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Sulfo-DBCO Group: Enables rapid, copper-free SPAAC click chemistry with azides.
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Terminal Amine: Couples efficiently with activated esters and electrophiles.
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PEG4 Spacer: Provides solubility, hydrophilicity, and compact spacing.
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Enhanced Solubility: Sulfonation improves aqueous compatibility.
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High Purity: Ensures reproducible results in sensitive workflows.
Applications:
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Bioconjugation: Links biomolecules through orthogonal click and amine chemistry.
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Probe Development: Builds water-soluble probes for imaging and diagnostics.
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Drug Delivery: Provides PEGylated scaffolds for therapeutic conjugates.
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Material Science: Functionalizes surfaces and nanomaterials with bioorthogonal handles.
Storage and Handling:
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Storage: Store at –20 °C in a tightly sealed, moisture- and light-protected container.
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Handling: Use aqueous or mixed solvents; avoid prolonged light exposure.
This product integrates sulfonated DBCO click chemistry with amine reactivity in a PEG4 scaffold, specifically offering high solubility and versatility for biological and chemical conjugation.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
