(S,R,S)-AHPC-PEG2-amine hydrochloride salt
(S,R,S)-AHPC-PEG2-amine hydrochloride salt is a high-purity heterobifunctional linker containing an AHPC (hydroxyproline-based ligand) moiety and a terminal primary amine, connected by a short PEG2 spacer specifically for improved solubility and flexibility. The hydrochloride salt form enhances stability and handling, making it especially suitable for targeted protein degradation and related conjugation strategies.
Key Features and Benefits
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AHPC Ligand: Binds selectively to the von Hippel–Lindau (VHL) E3 ligase, enabling PROTAC and other protein degradation applications.
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Primary Amine: Reacts efficiently with NHS esters, isocyanates, aldehydes, and other electrophiles.
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PEG2 Spacer: Enhances hydrophilicity and provides optimal spacing for bioconjugation.
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Hydrochloride Salt Form: Improves stability, ease of storage, and handling.
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High Purity: Supplied at >95% purity for reproducible performance in research and development.
Applications
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PROTAC synthesis and targeted protein degradation.
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Ligand-based drug discovery and chemical biology studies.
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Protein and peptide conjugation.
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Small-molecule probe development.
Storage and Handling
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Storage: Store at –20 °C, dry, and protected from light.
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Handling: Use anhydrous solvents (e.g., DMF, DMSO) and minimize exposure to moisture.
A specialized AHPC-based PEG2 amine linker in hydrochloride salt form, ideal for VHL-recruiting PROTAC synthesis and other targeted degradation strategies with enhanced solubility and handling.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
