SPDP-PEG7-acid

SPDP-PEG7-Acid

SPDP-PEG7-Acid is a versatile linker designed for bioconjugation, drug delivery, and material science applications. It combines a cleavable SPDP group (N-succinimidyl 3-(2-pyridyldithio)propionate) with a carboxylic acid terminus, connected by a 7-unit PEG spacer. This unique design significantly enhances water solubility, flexibility, and reactivity, making it highly effective in diverse settings.

Key Features

• Chemical Structure:
  • SPDP group enables thiol-reactive conjugation.
  • PEG7 spacer provides solubility and spatial flexibility.
  • Carboxylic acid supports further chemical modifications.
• Functional Groups:
  • Thiol-cleavable disulfide bond for reversible linking.
  • Reactive acid terminus for versatile coupling options.

Applications

1. Bioconjugation

SPDP-PEG7-Acid reacts efficiently with thiols to form reversible disulfide bonds. This feature also allows for temporary linkages or controlled release, making it a valuable tool for protein or peptide conjugation.

2. Drug Delivery

The PEG7 spacer enhances solubility and bioavailability, while the cleavable disulfide bond enables controlled drug release in reductive environments. This makes it ideal for creating responsive drug delivery systems.

3. Surface and Material Functionalization

With its SPDP group and carboxylic acid terminus, this linker supports dual functionalization of surfaces or nanoparticles. It combines thiol reactivity with carboxyl chemistry, enabling advanced material designs and biosensor applications.

Handling and Storage

Store SPDP-PEG7-Acid at −20°C in a dry, inert environment to maintain its reactivity. Protect it from moisture and light to preserve the functionality of the SPDP group. Use promptly after opening to ensure optimal performance.

Overall, SPDP-PEG7-Acid is a powerful and adaptable linker for bioconjugation, drug delivery, and material functionalization. Moreover, its cleavable thiol-reactive SPDP group, flexible PEG spacer, and reactive carboxylic acid terminus make it indispensable for applications requiring solubility, flexibility, and controlled release.