SPDP-PEG12-acid contains SPDP crosslinker and carboxylic acid moieties. SPDP contains a cleavable disulfide bond and readily react with amine and thiol groups. The linker can be used for intracellular crosslinking reactions. The terminal caboxylic acid can react with primary amines in the presence of coupling reagents, such as EDC, DCC and HATU to form stable amide bonds. The hydrophilic properties of the PEG linkers increase compound solubility in aqueous media.
Axispharm offers 3000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.