SMCC Linker: Advanced Crosslinker for Precise Bioconjugation
SMCC (N-succinimidyl 4-(N-maleimidomethyl)cyclohexane-1-carboxylate), CAS: 64987-85-5 is a versatile heterobifunctional crosslinker used extensively in pharmaceutical research and development. It features two reactive groups: a succinimidyl ester for reacting with primary amines and a maleimide group for interacting with sulfhydryl groups.
Key Features
- Dual Reactivity: Combines succinimidyl ester (amine-reactive) and maleimide (thiol-reactive) groups.
- Stable Conjugation: Forms strong covalent bonds with biomolecules.
- Versatile Applications: Useful in a range of bioconjugation processes.
SMCC Applications
- Antibody-Drug Conjugates (ADCs): Links antibodies with cytotoxic drugs for targeted cancer treatment, minimizing harm to healthy cells.
- Protein-Protein Conjugates: Creates stable complexes by reacting with cysteine and lysine residues.
- Protein-Nanoparticle Conjugates: Attaches proteins to nanoparticles for improved stability and functionality.
Advantages
- Precise Targeting: Enables controlled conjugation, enhancing therapeutic precision.
- Enhanced Stability: Provides robust, stable conjugates for reliable research and development.
- Reduced Side Effects: Facilitates the creation of targeted therapies with fewer off-target effects.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
