Poly(L-Glutamic Acid)-PEG-Poly(L-Glutamic Acid) (pGlu-PEG-pGlu), MW x 15K, n 5K is a functional triblock copolymer composed of poly(L-glutamic acid) (pGlu) and polyethylene glycol (PEG). It also has carboxyl-rich pGlu blocks positioned on both sides of the hydrophilic PEG segment. This grade combines approximately 15K pGlu with 5K PEG, providing a strong pGlu-rich architecture for polymer functionalization, bioconjugation, drug delivery, ionic interactions, and biomaterial research.
Key Features and Benefits
- Functional Triblock Copolymer: Combines carboxyl-rich pGlu blocks with a hydrophilic PEG central segment for polymer modification, conjugation, drug delivery, and biomaterial development.
- pGlu MW 15K: Provides substantial poly(amino acid) content with abundant pendant carboxyl groups for molecular interactions and chemical modification.
- PEG MW 5K: Provides a hydrophilic central segment specifically for aqueous compatibility, hydration, and steric stabilization.
- Strongly pGlu-Rich Architecture: The 3:1 pGlu-to-PEG molecular weight ratio provides high carboxyl-functional poly(L-glutamic acid) content while retaining a substantial hydrophilic PEG component.
- Carboxyl-Rich Polymer: The pGlu blocks specifically provide abundant pendant carboxyl groups that specifically support ionic interactions, chemical modification, and conjugation.
- pGlu-PEG-pGlu Architecture: pGlu blocks flank the hydrophilic PEG segment, providing multiple carboxyl groups for functionalization.
- Functionalizable Polymer Platform: Supports EDC/NHS coupling of pGlu carboxyl groups with amine-containing molecules.
Applications
- Polymer Functionalization: Provides abundant pendant carboxyl groups for chemical modification and attachment of functional molecules.
- Bioconjugation: Supports coupling with amine-containing peptides, proteins, ligands, and other biomolecules through activated carboxyl groups.
- Drug Delivery: Supports development of functional polymer systems, polymer-drug conjugates, and drug-delivery carriers.
- Ionic Complex Formation: Provides carboxyl-rich pGlu blocks for electrostatic interactions with positively charged molecules and materials.
- Hydrogel Development: Supports development of chemically crosslinked and ionically associated polymer networks for hydrogel research.
- Polymer Conjugates: Enables preparation of PEG-poly(amino acid) conjugates with drugs, peptides, targeting ligands, and other functional molecules.
- Biomaterial Research: Supports development of functional poly(amino acid)-PEG materials for coatings, matrices, hydrogels, and related biomaterial applications.
Storage and Handling
- Storage: Store at –20 °C in a tightly sealed container under dry conditions.
- Handling: Protect from moisture and excessive heat. Allow the material to equilibrate to room temperature before opening to minimize moisture condensation.
This product combines carboxyl-rich pGlu blocks with a hydrophilic PEG segment in a strongly pGlu-rich triblock architecture. It specifically supports polymer functionalization, bioconjugation, drug delivery, ionic complex formation, hydrogel development, and biomaterial research.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
