PLLA-PEG-Azide (PLLA-PEG-N3), MW x 10K, n 5K combines a 10K PLLA segment, 5K PEG segment, and terminal azide (–N₃) in a biodegradable block copolymer and specifically supports click chemistry, bioconjugation, nanoparticle development, and functional biomaterial research.
Key Features and Benefits
- Block Copolymer Structure: Combines hydrophobic poly(L-lactide) (PLLA) with hydrophilic polyethylene glycol (PEG) for amphiphilic polymer design.
- PLLA MW 10K: The 10K PLLA segment specifically provides a biodegradable hydrophobic polymer component suitable for polymer assembly and material research.
- PEG MW 5K: The 5K PEG segment provides a substantial hydrophilic component and flexible polymer spacer.
- Azide Functionality: Terminal azide (–N₃) specifically enables selective conjugation with compatible alkyne and cyclooctyne groups.
- CuAAC Click Chemistry: Supports copper-catalyzed azide-alkyne cycloaddition with terminal alkynes to form stable triazole linkages.
- SPAAC Click Chemistry: Compatible with strained cyclooctynes such as DBCO for copper-free click conjugation.
- Stable Triazole Formation: Click reactions provide stable covalent linkages specifically for polymer functionalization and conjugate development.
- Amphiphilic Character: The PLLA and PEG blocks provide distinct hydrophobic and hydrophilic regions for self-assembly and formulation research.
Applications
- Click Chemistry: Azide functionality supports CuAAC and SPAAC reactions with compatible click-reactive molecules.
- Bioconjugation: Attachment of peptides, ligands, dyes, and other appropriately functionalized molecules to the polymer.
- Ligand Conjugation: Enables preparation of functional polymer conjugates for targeting and molecular recognition research.
- Nanoparticle Research: Useful for developing functionalized polymeric nanoparticles and related nanoscale systems.
- Polymeric Micelles: Amphiphilic PLLA and PEG blocks support research into self-assembled polymeric structures.
- Drug Delivery Research: Suitable for developing and studying biodegradable polymer-based delivery systems.
- Surface Modification: Azide functionality enables click-mediated modification of compatible surfaces and materials.
- Biomaterial Research: Supports development of biodegradable, PEG-containing functional polymer systems.
Storage and Handling
- Storage: Store at –20 °C in a tightly sealed container under dry conditions.
- Handling: Protect from moisture and excessive heat. Allow the material to reach room temperature before opening to minimize condensation.
PLLA-PEG-Azide (PLLA-PEG-N3), MW x 10K, n 5K combines biodegradable PLLA, hydrophilic PEG, and click-reactive azide functionality, while its 10K PLLA and 5K PEG segments support nanoparticle, self-assembly, conjugation, and biomaterial research.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.