N(alpha)-PEG4-azide-L-Lysine-PEG3-azide provides a lysine-based bifunctional linker with PEG4 and PEG3 spacers bearing terminal azide groups. Its dual azide functionality specifically supports click chemistry, bioconjugation, molecular crosslinking, and multicomponent conjugate development.
Key Features and Benefits
- L-Lysine-Based Linker: Uses an L-lysine framework to organize two PEG-linked azide functionalities within one molecule.
- Dual Azide Functionality: Provides two terminal azide groups for orthogonal conjugation and multifunctional molecular design.
- PEG4 Spacer: The PEG4 segment provides a flexible, hydrophilic spacer that separates an azide group from the lysine framework.
- PEG3 Spacer: The PEG3 segment specifically provides additional hydrophilic spacing for conjugation and molecular functionalization.
- CuAAC Click Chemistry: Terminal azides react with suitable alkynes through copper-catalyzed azide-alkyne cycloaddition.
- SPAAC Click Chemistry: Azide groups react with strained cyclooctynes such as DBCO through copper-free click chemistry.
- Stable Triazole Formation: Azide-alkyne reactions specifically generate stable triazole linkages for conjugate construction.
- Hydrophilic Linker Design: PEG4 and PEG3 segments specifically provide flexible spacing and increase the hydrophilic character of the linker.
Applications
- Click Chemistry: Supports CuAAC and SPAAC reactions with compatible alkyne and strained cyclooctyne partners.
- Bioconjugation: Useful for constructing functional conjugates involving biomolecules, polymers, nanoparticles, and other research materials.
- Molecular Crosslinking: Dual azide groups enable linkage of compatible click-reactive molecular components.
- Multicomponent Conjugation: Supports molecular designs requiring two azide-reactive sites within a single linker.
- Protein and Peptide Modification: Useful for research involving click-based functionalization of appropriately modified proteins and peptides.
- Polymer Functionalization: Enables incorporation of lysine and PEG-based linker structures into functional polymer systems.
- Nanoparticle Functionalization: Supports click-based attachment of compatible molecules to appropriately functionalized nanoparticle systems.
- Biomaterial Research: Useful for developing functional materials containing hydrophilic PEG spacers and bioorthogonal reactive groups.
Storage and Handling
- Storage: Store according to the product specification in a tightly sealed container under dry conditions.
- Handling: Protect from moisture and excessive heat. Follow appropriate laboratory procedures when preparing solutions and performing click reactions.
N(alpha)-PEG4-azide-L-Lysine-PEG3-azide combines a lysine-based framework, hydrophilic PEG spacers, and dual azide functionality, while its bifunctional architecture supports click chemistry, crosslinking, bioconjugation, and functional material research.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
