PLLA-PEG-Azide (PLLA-PEG-N3), MW x 5K, n 5K combines a 5K PLLA segment, 5K PEG segment, and terminal azide (–N₃) in a biodegradable block copolymer and specifically supports click chemistry, bioconjugation, nanoparticle development, and functional biomaterial research.
Key Features and Benefits
- Block Copolymer Structure: Combines hydrophobic poly(L-lactide) (PLLA) with hydrophilic polyethylene glycol (PEG) for amphiphilic polymer design.
- PLLA MW 5K: The 5K PLLA segment provides a biodegradable hydrophobic component especially suitable for polymer assembly and material research.
- PEG MW 5K: The 5K PEG segment specifically provides a substantial hydrophilic component and flexible polymer spacer for conjugation and formulation studies.
- Azide Functionality: Terminal azide (–N₃) enables selective conjugation with compatible alkyne and cyclooctyne groups.
- CuAAC Click Chemistry: Supports copper-catalyzed azide-alkyne cycloaddition with terminal alkynes to form stable triazole linkages.
- SPAAC Click Chemistry: Compatible with strained cyclooctynes such as DBCO for copper-free click conjugation.
- Stable Triazole Formation: Click reactions specifically provide stable covalent linkages for polymer functionalization and conjugate development.
- Amphiphilic Character: The PLLA and PEG blocks provide distinct hydrophobic and hydrophilic regions for self-assembly and formulation research.
Applications
- Click Chemistry: Supports CuAAC and SPAAC reactions with compatible click-reactive molecules.
- Bioconjugation: Attachment of peptides, ligands, dyes, and other appropriately functionalized molecules.
- Ligand Conjugation: Preparation of functional polymer conjugates for targeting and molecular recognition research.
- Nanoparticle Research: Development of functionalized polymeric nanoparticles and related nanoscale systems.
- Polymeric Micelles: Amphiphilic PLLA and PEG blocks support research into self-assembled polymeric structures.
- Drug Delivery Research: Development and evaluation of biodegradable polymer-based delivery systems.
- Surface Modification: Click-mediated functionalization of compatible surfaces and materials.
- Biomaterial Research: Development of biodegradable, PEG-containing functional polymer systems.
Storage and Handling
- Storage: Store at –20 °C in a tightly sealed container under dry conditions.
- Handling: Protect from moisture and excessive heat. Allow the material to reach room temperature before opening to minimize condensation.
PLLA-PEG-Azide (PLLA-PEG-N3), MW x 5K, n 5K combines biodegradable PLLA, hydrophilic PEG, and click-reactive azide functionality, while its balanced PLLA and PEG block sizes support self-assembly, conjugation, nanoparticle, and biomaterial research.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.