PLGA-di-acid, MW 5K

PLGA-di-acid (PLGA-diacid), MW 5K is a low-molecular-weight linear biodegradable copolymer functionalized with dual terminal carboxylic acid groups. Synthesized via the copolymerization of D,L-lactide and glycolide, this polymer supports multiple optional LA/GA ratios including 50:50, 65:35, 75:25, 85:15, as well as customized proportions to fit diverse experimental requirements. Benefiting from its low molecular weight structure, the material possesses high terminal carboxyl reactivity and rapid biodegradation characteristics. The symmetric dual-acid terminals can efficiently undergo amide coupling, esterification and other conjugation reactions, serving as critical reactive intermediates for synthesizing amine-modified conjugates, block copolymers and crosslinkable biomaterials. Its degradation products are naturally metabolized in vivo, ensuring excellent biocompatibility and low biological toxicity. This 5K PLGA-di-acid is widely applied in small-molecule drug modification, high-activity nanoparticle preparation, and fundamental biomedical material derivatization research.