Phthalimidoxy-PEG1
Phthalimidoxy-PEG1 is a compact PEG reagent with a phthalimidoxy-protected aminooxy group. After deprotection, it enables oxime ligation with aldehydes or ketones, while the PEG1 spacer provides minimal flexibility and solubility for bioconjugation and synthesis.
Key Features and Benefits
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Phthalimidoxy Group: Provides protected aminooxy functionality, stable during synthesis, and releasable under mild hydrazinolysis conditions.
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PEG1 Spacer: Adds solubility and reduces steric hindrance in conjugation reactions.
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Compact Design: Maintains a small molecular footprint for precise modifications.
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Orthogonal Reactivity: After deprotection, enables oxime ligation with aldehydes and ketones.
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High Purity: Produced to ≥95% purity for reproducibility in research applications.
Applications
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Bioconjugation: Precursor for aminooxy-functionalized linkers enabling site-specific labeling.
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Probe Development: Builds oxime-based probes for imaging and diagnostics.
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Drug Delivery: Serves as a starting block for PEGylated therapeutics and carriers.
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Organic Synthesis: Useful intermediate for dual-reactive or multifunctional PEG linkers.
Storage and Handling
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Storage: Store at –20 °C in a dry, sealed container away from light and moisture.
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Handling: Use under inert atmosphere when possible; deprotect phthalimidoxy groups with hydrazine for aminooxy release.
This product is a compact PEG linker that provides protected aminooxy functionality, specifically enabling controlled oxime ligation and versatile use in synthesis and bioconjugation.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
