Bis-PEG2-NHS Ester (CAS 65869-63-8)
Bis-PEG2-NHS ester is a polyethylene glycol (PEG) derivative featuring two N-hydroxysuccinimide (NHS) ester groups. These reactive NHS esters facilitate efficient conjugation to primary amines, making this compound valuable in bioconjugation applications, including the development of antibody-drug conjugates (ADCs). The PEG2 spacer enhances solubility in aqueous media and provides flexibility to the conjugated molecules.
Chemical Properties:
- Chemical Formula: C₁₆H₂₀N₂O₁₀
- Molecular Weight: 400.34 g/mol
- Physical State: White solid
- Purity: ≥98%
Applications:
- Bioconjugation: Enables the attachment of PEG chains to proteins, peptides, or other amine-containing molecules, improving their solubility and stability.
- Antibody-Drug Conjugates (ADCs): Serves as a non-cleavable linker in the synthesis of ADCs, facilitating targeted drug delivery.
- Protein Labeling: Useful in labeling primary amines in proteins and peptides for various biochemical assays.
Storage and Handling:
- Storage Conditions: Store at -20°C in a dry environment to maintain stability.
- Safety Measures: Handle with appropriate protective equipment; consult the Safety Data Sheet (SDS) for detailed information.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
