PDLLA-Azide (PDLLA-N3), MW 20K is an azide-functionalized poly(DL-lactide) with a molecular weight of approximately 20K. It combines a biodegradable amorphous PDLLA backbone with terminal azide functionality specifically for click chemistry, bioconjugation, polymer functionalization, nanoparticle modification, and biomaterial research.
Key Features and Benefits
- Azide-Functionalized PDLLA: Combines biodegradable poly(DL-lactide) with a terminal azide group for chemical modification and conjugation.
- MW 20K: Provides a moderate molecular weight that balances polymer processability, biodegradable matrix formation, and functionalization.
- Azide Functionality: The terminal –N3 group provides a reactive site specifically for azide-alkyne click chemistry and related conjugation strategies.
- Biodegradable Polyester: The PDLLA backbone contains hydrolyzable ester linkages that specifically support gradual polymer degradation under appropriate conditions.
- Amorphous PDLLA Backbone: The random distribution of D- and L-lactide units limits crystallization and provides an amorphous polymer structure.
- Click Chemistry Platform: The azide terminus specifically supports Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC) with terminal alkynes.
- Copper-Free Conjugation: The azide group supports strain-promoted azide-alkyne cycloaddition (SPAAC) with compatible strained cyclooctynes.
- Versatile Functionalization: Terminal azide functionality enables attachment of compatible polymers, biomolecules, probes, ligands, and other functional components.
Applications
- CuAAC Click Chemistry: Supports conjugation with terminal alkyne-functionalized molecules, polymers, and surfaces.
- Copper-Free Click Chemistry: Supports SPAAC reactions with DBCO, BCN, and other compatible strained cyclooctyne-functionalized components.
- Bioconjugation: Provides terminal azide functionality for coupling PDLLA with compatible biomolecules and functional ligands.
- Polymer Functionalization: Enables preparation of functional PDLLA derivatives and more complex polymer architectures.
- Nanoparticle Functionalization: Supports preparation and surface modification of biodegradable polymer nanoparticles and related delivery systems.
- Drug Delivery: Supports development of functional biodegradable polymer systems for drug-delivery and controlled-release research.
- Surface Modification: Enables attachment of PDLLA to compatible alkyne- or cyclooctyne-functionalized surfaces and materials.
- Biomaterial Research: Supports development of functional biodegradable polymers, particles, coatings, composites, and related biomaterials.
Storage and Handling
- Storage: Store at –20 °C in a tightly sealed container under dry conditions. Protect from moisture and excessive heat.
- Handling: Protect from moisture and excessive heat. Allow the material to equilibrate to room temperature before opening to minimize moisture condensation.
PDLLA-Azide (PDLLA-N3), MW 20K provides an amorphous biodegradable PDLLA platform with terminal azide functionality for selective click chemistry and conjugation and specifically supports bioconjugation, polymer functionalization, nanoparticle modification, drug delivery, and biomaterial research.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.