α‑Hydroxyl‑ω‑azido‑poly(D,L‑lactide) (PDLLA‑N₃, MW 10K) is linear, mono‑azido‑terminated fully amorphous biodegradable aliphatic polyester. D‑lactide and L‑lactide repeat units are randomly distributed along polymer backbone, disrupting stereoregularity and eliminating crystalline domains. Compared with MW 2K and 5K PDLLA‑N₃, this 10 kDa variant exhibits further increased hydrophobicity and markedly slower but still homogeneous hydrolytic degradation. One chain terminus carries reactive azide (‑N₃), the opposite end retains inert hydroxyl (‑OH). Terminal azide participates in bioorthogonal click chemistry, including copper‑catalyzed azide‑alkyne cycloaddition (CuAAC) and copper‑free strain‑promoted azide‑alkyne cycloaddition (SPAAC) with DBCO / BCN moieties to form stable triazole linkages. It serves as a monofunctional macro‑monomer for bioconjugation, nanoparticle surface functionalization and post‑polymerization modification for long‑acting drug‑delivery biomedical research.
Key Features
- MW: 10000 Da, linear α‑hydroxyl‑ω‑azido‑terminated poly(D,L‑lactide)
- Fully amorphous non‑crystalline structure, random D/L‑lactide sequence, no melting point
- Higher hydrophobicity, slower yet uniform hydrolytic degradation versus 2K / 5K PDLLA‑N₃
- Excellent biocompatibility; degradation produces non‑toxic lactic‑acid metabolites
- Single reactive‑N₃ terminus; compatible with CuAAC & SPAAC click reactions; opposite end is inert hydroxyl ‑OH
- Narrow molecular‑weight distribution, stable batch‑to‑batch reproducibility
- Soluble in DCM, CHCl₃, THF, DMF, hot acetone; insoluble in water
- Azide end‑group is light‑sensitive; avoid prolonged light exposure and high‑temperature conditions
Applications
- Monofunctional building block for click‑bioconjugation with alkyne‑/DBCO‑activated peptides, targeting ligands and fluorescent dyes
- Azide‑functional surface modification of PDLLA‑based nanoparticles and microspheres for long‑term controlled‑release study
- Precursor for post‑modification of high‑molecular‑weight dense biodegradable polyester materials
- Research‑grade raw material for constructing bioorthogonal long‑circulating drug‑delivery carriers
Handling & Storage
- Store at −20 °C under dry inert nitrogen or argon atmosphere; strictly moisture‑proof, protected from light
- Keep hermetically sealed; moisture and heat may trigger ester hydrolysis and impair azide activity; avoid repeated freeze‑thaw cycles
- For research‑only use; not intended for clinical or diagnostic applications
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.