PDLLA-Azide (PDLLA-N3), MW 10K is an azide-functionalized poly(DL-lactide) with a molecular weight of approximately 10K. It combines a biodegradable amorphous PDLLA backbone with terminal azide functionality specifically for click chemistry, bioconjugation, polymer functionalization, nanoparticle modification, and biomaterial research.
Key Features and Benefits
- Azide-Functionalized PDLLA: Combines biodegradable poly(DL-lactide) with a terminal azide group for chemical modification and conjugation.
- MW 10K: Provides a lower molecular weight with good processability specifically for polymer functionalization, formulation, and conjugation research.
- Azide Functionality: The terminal –N3 group provides a reactive site for azide-alkyne click chemistry and related conjugation strategies.
- Biodegradable Polyester: The PDLLA backbone contains hydrolyzable ester linkages that specifically support gradual polymer degradation under appropriate conditions.
- Amorphous PDLLA Backbone: The random distribution of D- and L-lactide units limits crystallization and specifically provides an amorphous polymer structure.
- Good Processability: The lower molecular weight facilitates polymer dissolution, formulation, and chemical modification compared with higher-molecular-weight PDLLA grades.
- Click Chemistry Platform: The azide terminus supports Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC) with terminal alkynes.
- Copper-Free Conjugation: The azide group supports strain-promoted azide-alkyne cycloaddition (SPAAC) with compatible strained cyclooctynes.
Applications
- CuAAC Click Chemistry: Supports conjugation with terminal alkyne-functionalized molecules, polymers, and surfaces.
- Copper-Free Click Chemistry: Supports SPAAC reactions with DBCO, BCN, and other compatible strained cyclooctyne-functionalized components.
- Bioconjugation: Provides terminal azide functionality for coupling PDLLA with compatible biomolecules and functional ligands.
- Polymer Functionalization: Enables preparation of functional PDLLA derivatives and more complex polymer architectures.
- Nanoparticle Functionalization: Supports preparation and surface modification of biodegradable polymer nanoparticles and related delivery systems.
- Drug Delivery: Supports development of functional biodegradable polymer systems for drug-delivery and controlled-release research.
- Surface Modification: Enables attachment of PDLLA to compatible alkyne- or cyclooctyne-functionalized surfaces and materials.
- Biomaterial Research: Supports development of functional biodegradable polymers, particles, coatings, composites, and related biomaterials.
Storage and Handling
- Storage: Store at –20 °C in a tightly sealed container under dry conditions. Protect from moisture and excessive heat.
- Handling: Protect from moisture and excessive heat. Allow the material to equilibrate to room temperature before opening to minimize moisture condensation.
PDLLA-Azide (PDLLA-N3), MW 10K provides an amorphous biodegradable PDLLA platform with terminal azide functionality and good processability and specifically supports click chemistry, bioconjugation, polymer functionalization, nanoparticle modification, and biomaterial research.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.