PCL-PEG-Vinyl Sulfone (PCL-PEG-VS), MW x 2K, n 2K is a functional amphiphilic block copolymer composed of poly(ε-caprolactone) (PCL) and polyethylene glycol (PEG) with a terminal vinyl sulfone (VS) group. This grade combines approximately 2K PCL with 2K PEG, providing a balanced amphiphilic architecture and thiol-reactive functionality specifically for polymer conjugation, drug delivery, surface modification, and biomaterial research.
Key Features and Benefits
- Amphiphilic Block Copolymer: Combines hydrophobic PCL with hydrophilic PEG for polymer assembly, drug delivery, and biomaterial development.
- PCL MW 2K: Provides a biodegradable hydrophobic block specifically for polymer association, structural support, and interactions with hydrophobic compounds.
- PEG MW 2K: Provides a hydrophilic segment specifically for aqueous compatibility, hydration, and interfacial stabilization.
- Balanced Block Ratio: Equal PCL and PEG molecular weights provide balanced hydrophobic and hydrophilic character for amphiphilic polymer assembly.
- Vinyl Sulfone Functionality: Provides a reactive terminal group that readily undergoes Michael-type addition with thiol-containing molecules.
- Thiol-Reactive Polymer: Enables conjugation with thiol-containing peptides, proteins, ligands, and other molecules under suitable reaction conditions.
- Biodegradable Polymer Platform: Combines biodegradable PCL with hydrophilic PEG and reactive vinyl sulfone functionality for development of functional polymer systems.
Applications
- Polymer Conjugation: Supports covalent attachment of thiol-containing molecules through the terminal vinyl sulfone group.
- Bioconjugation: Enables conjugation with cysteine-containing peptides, proteins, and other thiol-bearing biomolecules.
- Nanoparticle Formulation: Supports preparation of functional polymeric nanoparticles and other nanoscale delivery systems.
- Drug Delivery: Supports development of polymeric carriers for hydrophobic compounds and functionalized drug-delivery systems.
- Surface Functionalization: Enables thiol-mediated attachment of ligands or biomolecules to PCL-PEG-based polymer surfaces.
- Hydrogel Development: Supports incorporation into thiol-reactive polymer networks and functional hydrogel systems.
- Biomaterial Research: Supports development of functional biodegradable polymers for biomaterials, coatings, scaffolds, and related research.
Storage and Handling
- Storage: Store at –20 °C in a tightly sealed container under dry conditions.
- Handling: Protect from moisture, excessive heat, and prolonged light exposure. Allow the material to equilibrate to room temperature before opening to minimize moisture condensation.
This product combines hydrophobic PCL, hydrophilic PEG, and terminal vinyl sulfone functionality in a balanced amphiphilic polymer. It specifically supports thiol-mediated conjugation, nanoparticle formulation, drug delivery, surface functionalization, hydrogel development, and biomaterial research.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.