PCL-PEG-Vinyl Sulfone (PCL-PEG-VS), MW x 10K, n 2K is a functional amphiphilic block copolymer composed of poly(ε-caprolactone) (PCL) and polyethylene glycol (PEG) with a terminal vinyl sulfone (VS) group. This grade combines approximately 10K PCL with 2K PEG, providing an especially strong PCL-rich architecture and thiol-reactive functionality for polymer conjugation, drug delivery, surface modification, and biomaterial research.
Key Features and Benefits
- Amphiphilic Block Copolymer: Combines hydrophobic PCL with hydrophilic PEG for polymer assembly, drug delivery, and biomaterial development.
- PCL MW 10K: Provides a biodegradable hydrophobic block for structural support, hydrophobic interactions, and incorporation of hydrophobic compounds.
- PEG MW 2K: Provides a hydrophilic segment specifically for aqueous compatibility and interfacial stabilization.
- Strongly PCL-Rich Architecture: The 5:1 PCL-to-PEG molecular weight ratio strongly favors hydrophobic interactions, polymer association, and hydrophobic domain formation while retaining a hydrophilic PEG component.
- Vinyl Sulfone Functionality: Provides a reactive terminal group that readily undergoes Michael-type addition with thiol-containing molecules.
- Thiol-Reactive Polymer: Enables conjugation with thiol-containing peptides, proteins, ligands, and other molecules under suitable reaction conditions.
- Biodegradable Polymer Platform: Combines biodegradable PCL with hydrophilic PEG and reactive vinyl sulfone functionality for development of functional polymer systems.
Applications
- Polymer Conjugation: Supports covalent attachment of thiol-containing molecules through the terminal vinyl sulfone group.
- Bioconjugation: Enables conjugation with cysteine-containing peptides, proteins, and other thiol-bearing biomolecules.
- Nanoparticle Formulation: Supports preparation of PCL-rich functional polymeric nanoparticles and other nanoscale delivery systems.
- Drug Delivery: Supports development of polymeric carriers for hydrophobic compounds and functionalized drug-delivery systems.
- Surface Functionalization: Enables thiol-mediated attachment of ligands or biomolecules to PCL-PEG-based polymer surfaces.
- Hydrogel Development: Supports incorporation into thiol-reactive polymer networks and functional hydrogel systems.
- Biomaterial Research: Supports development of functional biodegradable polymers for biomaterials, coatings, scaffolds, and related research.
Storage and Handling
- Storage: Store at –20 °C in a tightly sealed container under dry conditions.
- Handling: Protect from moisture, excessive heat, and prolonged light exposure. Allow the material to equilibrate to room temperature before opening to minimize moisture condensation.
This product combines a hydrophobic PCL block, hydrophilic PEG segment, and terminal vinyl sulfone functionality in a strongly PCL-rich amphiphilic polymer. It specifically supports thiol-mediated conjugation, nanoparticle formulation, drug delivery, surface functionalization, hydrogel development, and biomaterial research.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.