PCL-PEG-SH, MW x 2K, n 1K is a thiol-functionalized amphiphilic block copolymer. It combines a 2K poly(ε-caprolactone) (PCL) block with a 1K polyethylene glycol (PEG) block, and its PCL-rich architecture favors hydrophobic assembly and drug incorporation, while the terminal thiol enables conjugation and surface functionalization.
Key Features and Benefits
- Amphiphilic Copolymer: Combines hydrophobic PCL with hydrophilic PEG for polymer assembly and drug delivery.
- PCL MW 2K: Provides a biodegradable hydrophobic segment for core formation and hydrophobic compound incorporation.
- PEG MW 1K: Provides a short hydrophilic segment specifically for interfacial stabilization and surface functionality.
- PCL-Rich Architecture: The 2:1 PCL-to-PEG molecular weight ratio favors hydrophobic interactions and core-forming assemblies.
- Thiol Functionalization: Provides a terminal sulfhydryl group specifically for conjugation and surface modification.
- Versatile Reactivity: The thiol reacts with maleimides and other thiol-reactive functional groups under suitable conditions.
Applications
- Bioconjugation: Enables coupling with maleimide-functionalized peptides, proteins, ligands, and other molecules.
- Nanoparticle Functionalization: Supports functionalized nanoparticles, micelles, and amphiphilic polymer assemblies.
- Drug Delivery: Supports polymeric carriers for hydrophobic compounds and controlled-delivery research.
- Surface Functionalization: Terminal thiol supports attachment to compatible thiol-reactive surfaces and materials.
- Crosslinking Research: Supports preparation of functional polymer networks using thiol-reactive chemistry.
Storage and Handling
- Storage: Store at –20 °C in a tightly sealed container under dry conditions.
- Handling: Protect from moisture, heat, and oxidizing conditions. Thiol groups can oxidize to form disulfides.
PCL-PEG-SH, MW x 2K, n 1K combines a PCL-rich architecture with terminal thiol functionality and specifically supports hydrophobic polymer assembly, bioconjugation, drug delivery, and surface functionalization.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.